Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.57 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.56 |
| ▸ | HTT | P42858 | 3/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | PTBP1 | P26599 | 1/20 | 0.56 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | GPR142 | Q7Z601 | 1/20 | 0.50 |
| ▸ | PRKACA | P17612 | 1/20 | 0.49 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15738283 | 0.79 | TBK1 (0.57) | TBK1SMN1; SMN2NPC1RAB9AGPR142 | |
| SCHEMBL17318683 | 0.78 | NPC1 (0.77) | ALDH1A1TBK1SMN1; SMN2HTTNPC1 | |
| SCHEMBL7530819 | 0.78 | RAB9A (0.62) | ALDH1A1SMN1; SMN2HTTLMNAPTBP1 | |
| SCHEMBL15737508 | 0.77 | TBK1 (0.58) | TBK1GPR142PRKACAROCK1MAPK1 | |
| SCHEMBL15737873 | 0.76 | TBK1 (0.58) | TBK1SMN1; SMN2LMNANPC1KMT2A | |
| SCHEMBL15738606 | 0.75 | TBK1 (0.60) | ALDH1A1TBK1SMN1; SMN2GAAGPR142 | |
| SCHEMBL15737940 | 0.74 | PRKACA (0.47) | ALDH1A1TBK1HTTLMNAKMT2A | |
| SCHEMBL13357509 | 0.74 | PRKACA (0.70) | ALDH1A1SMN1; SMN2GAAGPR142PRKACA | |
| SCHEMBL6667286 | 0.74 | ALDH1A1 (1.00) | ALDH1A1SMN1; SMN2HTTLMNAPTBP1 | |
| SCHEMBL15737242 | 0.73 | IKBKE (0.59) | ALDH1A1TBK1SMN1; SMN2LMNANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9249114-B2 | Thiazole derivatives | MERCK PATENT GMBH (DE) | 2016-02-02 | — | — | US | claimed |
| US-20140148457-A1 | Thiazole derivatives | MERCK PATENT GMBH (DE) | 2014-05-29 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140148457-A1 | Thiazole derivatives | TBK1, IRAK1, IRF3 | ALDH1A1 3473/4885TBK1 1/4885SMN1; SMN2 3743/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.