Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.37 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.37 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | TRPC3 | Q13507 | 2/20 | 0.37 |
| ▸ | TRPC7 | Q9HCX4 | 2/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1573883 | 0.86 | GAA (0.41) | SMN1; SMN2NPC1RAB9ACYP2C19HTT | |
| SCHEMBL1573885 | 0.79 | GAA (0.36) | SMN1; SMN2NPC1RAB9ACYP2C19GAA | |
| SCHEMBL1573937 | 0.79 | LIPE (0.38) | GAA | |
| SCHEMBL1573836 | 0.79 | GAA (0.36) | SMN1; SMN2RAB9ACYP2C19HTTGAA | |
| SCHEMBL1573808 | 0.79 | GAA (0.47) | HTTGAAMAPTALDH1A1TDP1 | |
| SCHEMBL1573815 | 0.77 | GAA (0.43) | SMN1; SMN2NPC1RAB9ACYP2C19HTT | |
| SCHEMBL1573859 | 0.76 | GAA (0.41) | SMN1; SMN2RAB9ACYP2C19HTTGAA | |
| SCHEMBL1574115 | 0.76 | GAA (0.41) | SMN1; SMN2RAB9ACYP2C19HTTGAA | |
| SCHEMBL1573851 | 0.75 | SPR (0.37) | — | |
| SCHEMBL1573819 | 0.75 | GAA (0.40) | SMN1; SMN2NPC1RAB9AGAAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1713779-B1 | INDAZOLE DERIVATIVES AS INHIBITORS OF HORMONE-SENSITIVE LIPASES | SANOFI AVENTIS DEUTSCHLAND (DE) | 2011-04-13 | — | — | EP | disclosed |