Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | RBP4 | P02753 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | HTR7 | P34969 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1573607 | 0.86 | TP53 (0.48) | GAAALDH1A1MEN1KMT2ATP53 | |
| SCHEMBL1573650 | 0.83 | GAA (0.45) | GAAALDH1A1MEN1KMT2ACYP1A2 | |
| SCHEMBL1573877 | 0.83 | KDM4E (0.41) | GAAALDH1A1MEN1KMT2ACYP1A2 | |
| SCHEMBL4248216 | 0.82 | GAA (0.49) | GAAALDH1A1MEN1KMT2ACYP1A2 | |
| SCHEMBL4882411 | 0.78 | GAA (0.56) | GAAALDH1A1MEN1KMT2ACYP1A2 | |
| SCHEMBL4244294 | 0.77 | GAA (0.46) | GAAALDH1A1MEN1KMT2ACYP1A2 | |
| SCHEMBL1562548 | 0.75 | KDM4E (0.54) | ALDH1A1KMT2ACYP3A4KDM4EHPGD | |
| SCHEMBL1573600 | 0.75 | RAB9A (0.58) | GAAALDH1A1MEN1KMT2ACYP1A2 | |
| SCHEMBL27249780 | 0.73 | RBP4 (0.59) | GAAALDH1A1MEN1KMT2ACYP3A4 | |
| SCHEMBL4885142 | 0.72 | ALDH1A1 (0.54) | GAAALDH1A1MEN1KMT2ACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1713779-B1 | INDAZOLE DERIVATIVES AS INHIBITORS OF HORMONE-SENSITIVE LIPASES | SANOFI AVENTIS DEUTSCHLAND (DE) | 2011-04-13 | — | — | EP | disclosed |
| EP-1713779-A1 | INDAZOLE DERIVATIVES AS INHIBITORS OF HORMONE-SENSITIVE LIPASES | Sanofi-Aventis Deutschland GmbH (DE) | 2006-10-25 | — | — | EP | disclosed |
| WO-2005073199-A1 | INDAZOLE DERIVATIVES AS INHIBITORS OF HORMONE-SENSITIVE LIPASES | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2005-08-11 | — | — | WO | disclosed |