Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HTR3A | P46098 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | LIPE | Q05469 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1573876 | 0.82 | GAA (0.56) | GAAALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL1573650 | 0.76 | GAA (0.45) | GAAALDH1A1MEN1KMT2ACYP1A2 | |
| SCHEMBL10459212 | 0.72 | GAA (0.66) | GAAALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL10458731 | 0.71 | GAA (0.64) | GAAALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL829640 | 0.71 | GAA (0.64) | GAAALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL4244294 | 0.70 | GAA (0.46) | GAAALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL9461066 | 0.70 | GAA (0.67) | GAAALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL1573607 | 0.69 | TP53 (0.48) | GAAALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL470967 | 0.67 | GAA (1.00) | GAAALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL1574219 | 0.67 | GAA (0.48) | GAAALDH1A1SMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7528155-B2 | Indazole derivatives as inhibitors of hormone sensitive lipase | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2009-05-05 | — | — | US | disclosed |
| US-20050197348-A1 | Indazole derivatives as inhibitors of hormone sensitive lipase | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2005-09-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050197348-A1 | Indazole derivatives as inhibitors of hormone sensitive lipase | LIPE, PNLIP, CEL | GAA 50/4885ALDH1A1 479/4885SMN1; SMN2 4778/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.