Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | HTR2A | P28223 | 1/20 | 0.47 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.47 |
| ▸ | PPARA | Q07869 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
| ▸ | FBP1 | P09467 | 3/20 | 0.40 |
| ▸ | CNR2 | P34972 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MMP8 | P22894 | 1/20 | 0.38 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12713184 | 0.90 | TSHR (0.48) | TSHRABCB11CYP1A2CYP3A4HTR2A | |
| SCHEMBL12713204 | 0.85 | ALDH1A1 (0.43) | TSHRABCB11CYP1A2CYP3A4HTR2A | |
| SCHEMBL15814208 | 0.81 | KDM4E (0.42) | TSHRCYP1A2CYP3A4PPARAMAPT | |
| SCHEMBL12802659 | 0.80 | RIPK1 (0.49) | TSHRABCB11CYP1A2CYP3A4HTR2A | |
| SCHEMBL29960917 | 0.77 | ABCB11 (0.49) | TSHRABCB11CYP1A2CYP3A4HTR2A | |
| SCHEMBL7886929 | 0.77 | GAA (0.49) | GAAMAPTALDH1A1ALOX15MEN1 | |
| SCHEMBL31053255 | 0.77 | GAA (0.49) | GAAMAPTALDH1A1ALOX15MEN1 | |
| SCHEMBL2557165 | 0.76 | CYP3A4 (0.58) | TSHRABCB11CYP1A2CYP3A4HTR2A | |
| SCHEMBL12713132 | 0.74 | ALDH1A1 (0.44) | TSHRCYP3A4PPARAGAAALDH1A1 | |
| SCHEMBL15740348 | 0.74 | CYP4F2 (0.50) | TSHRGAAALDH1A1ALOX15MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9499497-B2 | Compounds useful as inhibitors of indoleamine 2,3-dioxygenase | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2016-11-22 | — | — | US | disclosed |
| US-9499497-B2 | Compounds useful as inhibitors of indoleamine 2,3-dioxygenase | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2016-11-22 | — | — | US | disclosed |
| US-9499497-B2 | Compounds useful as inhibitors of indoleamine 2,3-dioxygenase | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2016-11-22 | — | — | US | disclosed |
| US-20150336903-A1 | COMPOUNDS USEFUL AS INHIBITORS OF INDOLEAMINE 2,3-DIOXYGENASE | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2015-11-26 | — | — | US | disclosed |
| US-20150336903-A1 | COMPOUNDS USEFUL AS INHIBITORS OF INDOLEAMINE 2,3-DIOXYGENASE | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2015-11-26 | — | — | US | disclosed |
| EP-2922847-A1 | COMPOUNDS USEFUL AS INHIBITORS OF INDOLEAMINE 2,3-DIOXYGENASE | Vertex Pharmaceuticals Incorporated (US) | 2015-09-30 | — | — | EP | disclosed |
| US-9073875-B2 | Compounds useful as inhibitors of indoleamine 2,3-dioxygenase | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2015-07-07 | — | — | US | disclosed |
| US-9073875-B2 | Compounds useful as inhibitors of indoleamine 2,3-dioxygenase | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2015-07-07 | — | — | US | disclosed |
| US-9073875-B2 | Compounds useful as inhibitors of indoleamine 2,3-dioxygenase | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2015-07-07 | — | — | US | disclosed |
| US-20140179699-A1 | COMPOUNDS USEFUL AS INHIBITORS OF INDOLEAMINE 2,3-DIOXYGENASE | VERTEX PHARMACEUTICALS INCORPORATED | 2014-06-26 | — | — | US | disclosed |
| US-20140179699-A1 | COMPOUNDS USEFUL AS INHIBITORS OF INDOLEAMINE 2,3-DIOXYGENASE | VERTEX PHARMACEUTICALS INCORPORATED | 2014-06-26 | — | — | US | disclosed |
| WO-2014081689-A1 | COMPOUNDS USEFUL AS INHIBITORS OF INDOLEAMINE 2,3-DIOXYGENASE | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2014-05-30 | — | — | WO | disclosed |
| WO-2014081689-A1 | COMPOUNDS USEFUL AS INHIBITORS OF INDOLEAMINE 2,3-DIOXYGENASE | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2014-05-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150336903-A1 | COMPOUNDS USEFUL AS INHIBITORS OF INDOLEAMINE 2,3-DIOXYGENASE | IDO1, IDO2, INMT | TSHR 3911/4885ABCB11 1623/4885CYP1A2 39/4885 |
| US-20140179699-A1 | COMPOUNDS USEFUL AS INHIBITORS OF INDOLEAMINE 2,3-DIOXYGENASE | IDO1, IDO2, INMT | TSHR 3911/4885ABCB11 1623/4885CYP1A2 39/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.