Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.33 |
| ▸ | TMEM97 | Q5BJF2 | 6/20 | 0.32 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.31 |
| ▸ | CES2 | O00748 | 1/20 | 0.31 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.31 |
| ▸ | GLA | P06280 | 1/20 | 0.31 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.31 |
| ▸ | AR | P10275 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15740426 | 0.92 | HRH3 (0.42) | NPSR1HRH3TMEM97SIRT6MAPK1 | |
| SCHEMBL15740495 | 0.92 | HRH3 (0.34) | LMNASMN1; SMN2HTTHRH3TMEM97 | |
| SCHEMBL15740411 | 0.92 | HRH3 (0.37) | LMNASMN1; SMN2HTTHRH3TMEM97 | |
| SCHEMBL15740360 | 0.91 | TMEM97 (0.36) | LMNASMN1; SMN2HPGDHTTHRH3 | |
| SCHEMBL15740352 | 0.89 | SIRT6 (0.41) | LMNASMN1; SMN2HPGDHTTMEN1 | |
| SCHEMBL15740438 | 0.87 | AR (0.35) | HRH3ARCNR1CNR2MCHR1 | |
| SCHEMBL15740436 | 0.86 | LMNA (0.36) | LMNASMN1; SMN2HPGDHTTMEN1 | |
| SCHEMBL2126360 | 0.83 | SERPINE1 (0.45) | LMNASMN1; SMN2HPGDHTTMEN1 | |
| SCHEMBL2124155 | 0.83 | SERPINE1 (0.37) | LMNASMN1; SMN2HTTMEN1KMT2A | |
| SCHEMBL2125848 | 0.83 | SERPINE1 (0.37) | LMNASMN1; SMN2HTTMEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2922845-A2 | ANTHELMINTIC COMPOUNDS AND COMPOSITIONS AND METHOD OF USING THEREOF | Merial, Inc. (US) | 2015-09-30 | — | — | EP | disclosed |
| WO-2014081697-A2 | ANTHELMINTIC COMPOUNDS AND COMPOSITIONS AND METHOD OF USING THEREOF | MERIAL LIMITED (US) | 2014-05-30 | — | — | WO | disclosed |