Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 5/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.45 |
| ▸ | MEN1 | O00255 | 4/20 | 0.45 |
| ▸ | HPGD | P15428 | 4/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1573607 | 0.75 | TP53 (0.48) | GAASMN1; SMN2KMT2AMEN1HPGD | |
| SCHEMBL5640491 | 0.74 | FAAH (0.56) | SMN1; SMN2LMNARECQL | |
| SCHEMBL23782714 | 0.72 | ELANE (0.49) | SMN1; SMN2LMNAKMT2AHPGDALDH1A1 | |
| SCHEMBL1573644 | 0.70 | RAB9A (0.39) | SMN1; SMN2HPGDALDH1A1HSD17B10KDM4E | |
| SCHEMBL1573842 | 0.70 | ACHE (0.47) | GAASMN1; SMN2KMT2AMEN1HPGD | |
| SCHEMBL5643813 | 0.69 | NPC1 (0.52) | GAASMN1; SMN2LMNAKMT2AMEN1 | |
| SCHEMBL1573967 | 0.69 | ACHE (0.44) | GAASMN1; SMN2KMT2AMEN1HPGD | |
| SCHEMBL1573664 | 0.68 | ALDH1A1 (0.41) | SMN1; SMN2KMT2AMEN1HPGDALDH1A1 | |
| SCHEMBL27872556 | 0.68 | ALDH1A1 (0.63) | GAASMN1; SMN2LMNAKMT2AMEN1 | |
| SCHEMBL6852832 | 0.67 | ELANE (0.53) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1713779-B1 | INDAZOLE DERIVATIVES AS INHIBITORS OF HORMONE-SENSITIVE LIPASES | SANOFI AVENTIS DEUTSCHLAND (DE) | 2011-04-13 | — | — | EP | disclosed |