Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 1/20 | 0.48 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.48 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.48 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.48 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.48 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.46 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.46 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 5/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.45 |
| ▸ | FAAH | O00519 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1574020 | 0.87 | L3MBTL1 (0.47) | ALDH1A1POLBSMN1; SMN2GAAABHD6 | |
| SCHEMBL1573860 | 0.84 | KDM4E (0.47) | ALDH1A1KDM4EGAAABHD6NOTUM | |
| SCHEMBL31358086 | 0.81 | SMN1; SMN2 (0.50) | ALDH1A1KDM4EPOLBSMN1; SMN2GAA | |
| SCHEMBL1573954 | 0.81 | SMN1; SMN2 (0.50) | ALDH1A1KDM4EPOLBSMN1; SMN2GAA | |
| SCHEMBL1573600 | 0.77 | RAB9A (0.58) | ALDH1A1KDM4ESMN1; SMN2GAAMEN1 | |
| SCHEMBL1573857 | 0.74 | RAB9A (0.44) | ALDH1A1KDM4ESMN1; SMN2GAAROCK2 | |
| SCHEMBL1573950 | 0.73 | ALDH1A1 (0.61) | ALDH1A1KDM4ESMN1; SMN2GAAMEN1 | |
| SCHEMBL15355311 | 0.73 | SMN1; SMN2 (0.59) | ALDH1A1SMN1; SMN2GAAABHD6NOTUM | |
| SCHEMBL29589853 | 0.73 | SMN1; SMN2 (0.59) | ALDH1A1SMN1; SMN2GAAABHD6NOTUM | |
| SCHEMBL20899542 | 0.72 | NOTUM (0.62) | ALDH1A1SMN1; SMN2ABHD6NOTUMMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1713779-B1 | INDAZOLE DERIVATIVES AS INHIBITORS OF HORMONE-SENSITIVE LIPASES | SANOFI AVENTIS DEUTSCHLAND (DE) | 2011-04-13 | — | — | EP | disclosed |