SCHEMBL157603

SCHEMBL157603

N#Cc1cc(F)c(F)c(F)c1

nearest known ligand 0.42

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
CES2 O00748 1/20 0.42
CES1 P23141 1/20 0.42
TRPV4 Q9HBA0 3/20 0.39
TTR P02766 2/20 0.39
ALB P02768 2/20 0.39
MEN1 O00255 1/20 0.39
KMT2A Q03164 1/20 0.39
KIF11 P52732 1/20 0.36
EGLN2 Q96KS0 2/20 0.36
VCAM1 P19320 2/20 0.36
TSHR P16473 1/20 0.35
HDAC8 Q9BY41 1/20 0.35
CYP11B1 P15538 1/20 0.33
CYP11B2 P19099 1/20 0.33
HTR7 P34969 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9491002 0.85 TRPV4 (0.40) CES2CES1TRPV4TTRALB
SCHEMBL29891425 0.83 GRM5 (0.43) TRPV4TTRALBMEN1KMT2A
SCHEMBL18002603 0.83 TTR (0.41) CES2CES1TRPV4TTRALB
SCHEMBL20912550 0.83 TTR (0.52) CES2CES1TRPV4TTRALB
SCHEMBL9224719 0.83 EGLN2 (0.40) TRPV4TTRALBMEN1KMT2A
SCHEMBL23099521 0.83 TTR (0.52) CES2CES1TRPV4TTRALB
SCHEMBL30297979 0.83 TTR (0.52) CES2CES1TRPV4TTRALB
SCHEMBL8463144 0.83 GRM5 (0.43) TRPV4TTRALBMEN1KMT2A
SCHEMBL6649045 0.80 TRPV4 (0.61) TRPV4TTRALBMEN1KMT2A
SCHEMBL3171347 0.79 KIF11 (0.49) TRPV4KIF11

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 430 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118993958-A Method for synthesizing polyfluoroaryl sulfide 三峡大学 2024-11-22 CN claimed
US-8952083-B2 Fluorocopolymer composition and its production process ASAHI GLASS COMPANY, LIMITED (JP) 2015-02-10 US claimed
CN-102531833-A Preparation method of polyfluoroethane compound SHANGHAI SINOFLUORO SCIENT CO 2012-07-04 CN claimed
EP-4720044-A1 AROMATIC AMIDES AND CONJUGATES THEREOF AS BINDERS TO TEAD Beactica Therapeutics AB (SE) 2026-04-08 EP disclosed
US-12472181-B2 Compounds and pharmaceutical compositions thereof for the treatment of inflammatory disorders GALAPAGOS NV (BE) 2025-11-18 US disclosed
WO-2025137605-A1 COMPOUNDS FOR TARGETED DEGRADATION OF PROTO-ONCOGENE TYROSINE PROTEIN KINASE RECEPTOR C4 THERAPEUTICS, INC. (US) 2025-06-26 WO disclosed
CN-114423758-B Antibacterial compounds 爱尔兰詹森科学公司 2025-05-27 CN disclosed
US-12297322-B2 Triazine-based membranes for gas separation UT-BATTELLE, LLC (US) 2025-05-13 US disclosed
WO-2025070482-A1 COMPOUND, LIGHT-EMITTING MATERIAL, AND ORGANIC LIGHT-EMITTING ELEMENT 株式会社Kyulux 2025-04-03 WO disclosed
EP-3774786-B1 METHOD FOR THE PREPARATION OF A 2,4,5-TRISUBSTITUTED 1,2,4-TRIAZOLONE BAYER AG (DE) 2024-12-25 EP disclosed
WO-2024240840-A1 AROMATIC AMIDES AND CONJUGATES THEREOF AS BINDERS TO TEAD BEACTICA THERAPEUTICS AB (SE) 2024-11-28 WO disclosed
EP-0391591-B1 Pyrimidine derivative and liquid crystal composition incorporating the same SEIKO EPSON CORP (JP) 1994-06-15 EP disclosed
EP-0387032-B1 TRIFLUOROBENZENE DERIVATIVES AND LIQUID CRYSTAL COMPOSITIONS CONTAINING THE SAME CHISSO CORP (JP) 1993-06-16 EP disclosed
WO-1992018467-A1 CYANOPHENOXYNAPHTHYL OXYCARBOXYLIC ACID DERIVATIVES BAYER AKTIENGESELLSCHAFT (DE) 1992-10-29 WO disclosed
EP-0270964-B1 PROCESS FOR OBTAINING SUBSTITUTED FLUOROBENZENES BAYER AG (DE) 1992-07-08 EP disclosed
US-5032313-A Trifluorobenzene derivative and liquid crystal composition containing the same CHISSO CORPORATION (JP) 1991-07-16 US disclosed
EP-0391591-A2 Pyrimidine derivative and liquid crystal composition incorporating the same SEIKO EPSON CORPORATION (JP) 1990-10-10 EP disclosed
EP-0387032-A1 Trifluorobenzene derivatives and liquid crystal compositions containing the same Chisso Corporation (JP) 1990-09-12 EP disclosed
US-4868347-A SOLVENT EXTRACTION BAYER AKTIENGESELLSCHAFT (DE) 1989-09-19 US disclosed
EP-0270964-A2 Process for obtaining substituted fluorobenzenes BAYER AG (DE) 1988-06-15 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12472181-B2 Compounds and pharmaceutical compositions thereof for the treatment of inflammatory disorders IL15, IL2, IL33 CES2 3035/4885CES1 1544/4885TRPV4 3854/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.