Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.43 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.43 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.42 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.42 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.42 |
| ▸ | TTR | P02766 | 1/20 | 0.41 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.40 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.40 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.40 |
| ▸ | LTA4H | P09960 | 1/20 | 0.39 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.39 |
| ▸ | PRKCI | P41743 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | F10 | P00742 | 1/20 | 0.35 |
| ▸ | IDO1 | P14902 | 1/20 | 0.35 |
| ▸ | AGXT | P21549 | 1/20 | 0.35 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.35 |
| ▸ | NOS3 | P29474 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL551531 | 0.86 | TSHR (0.46) | TSHRSMN1; SMN2CYP4F2CYP4A11ENPP2 | |
| SCHEMBL17428958 | 0.82 | MAPK1 (0.44) | TSHRSMN1; SMN2CYP4F2CYP4A11 | |
| SCHEMBL804931 | 0.82 | CYP4F2 (0.39) | TSHRCYP4F2CYP4A11IDO1AGXT | |
| SCHEMBL25485110 | 0.79 | IDO1 (0.47) | CYP4F2CYP4A11IDO1AGXTTAAR1 | |
| SCHEMBL96382 | 0.75 | TAAR1 (0.60) | IDO1AGXTTAAR1 | |
| SCHEMBL16845934 | 0.75 | TSHR (0.47) | TSHRSMN1; SMN2CYP4F2CYP4A11ENPP2 | |
| SCHEMBL29587500 | 0.75 | TAAR1 (0.60) | IDO1AGXTTAAR1 | |
| SCHEMBL14724397 | 0.75 | TSHR (0.47) | TSHRSMN1; SMN2CYP4F2CYP4A11ENPP2 | |
| SCHEMBL18834801 | 0.75 | TSHR (0.47) | TSHRSMN1; SMN2CYP4F2CYP4A11ENPP2 | |
| SCHEMBL16902891 | 0.75 | TSHR (0.56) | TSHRSMN1; SMN2CYP4F2CYP4A11ENPP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111386116-B | Compound with PD-L1 inhibitory activity, preparation method and application thereof | 上海轶诺药业有限公司 | 2022-06-14 | — | — | CN | disclosed |
| CN-111386116-A | Compound with PD-L1 inhibitory activity, preparation method and application thereof | 上海轶诺药业有限公司 | 2020-07-07 | — | — | CN | disclosed |
| US-20180105518-A1 | TRKA KINASE INHIBITORS, COMPOSITIONS AND METHODS THEREOF | MERCK SHARP & DOHME CORP. (US) | 2018-04-19 | — | — | US | disclosed |
| US-20140155635-A1 | RESORCYLIC ACID LACTONE COMPOUNDS | KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY (KR) | 2014-06-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180105518-A1 | TRKA KINASE INHIBITORS, COMPOSITIONS AND METHODS THEREOF | NGFR, NTRK2, NGF | TSHR 536/4885SMN1; SMN2 1852/4885CYP4F2 3776/4885 |
| US-20140155635-A1 | RESORCYLIC ACID LACTONE COMPOUNDS | MCL1, PRKCA, REL | TSHR 4440/4885SMN1; SMN2 4498/4885CYP4F2 4051/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.