Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SOS1 | Q07889 | 1/20 | 0.40 |
| ▸ | HSPB1 | P04792 | 1/20 | 0.40 |
| ▸ | LTA4H | P09960 | 6/20 | 0.39 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.39 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | SCN4A | P35499 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 2/20 | 0.34 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.34 |
| ▸ | BAX | Q07812 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | CES2 | O00748 | 1/20 | 0.34 |
| ▸ | CES1 | P23141 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27692978 | 0.98 | SOS1 (0.39) | SOS1HSPB1LTA4HFFAR1EPHX2 | |
| SCHEMBL28072263 | 0.85 | LTA4H (0.55) | SOS1LTA4HTSHRMEN1KMT2A | |
| SCHEMBL8155454 | 0.85 | LTA4H (0.43) | LTA4HTSHRMEN1KMT2AALDH1A1 | |
| SCHEMBL61732 | 0.83 | LTA4H (0.57) | SOS1LTA4HTSHRMEN1KMT2A | |
| SCHEMBL920377 | 0.82 | VEGFA (0.33) | LTA4HFFAR1FFAR4TSHR | |
| SCHEMBL9450784 | 0.81 | LTA4H (0.42) | LTA4HTSHRMEN1KMT2AALDH1A1 | |
| SCHEMBL921761 | 0.81 | KDM4E (0.39) | FFAR1FFAR4ALDH1A1 | |
| SCHEMBL4909322 | 0.80 | MAPT (0.47) | LTA4HTSHRMEN1KMT2AALDH1A1 | |
| SCHEMBL920289 | 0.80 | TEAD4 (0.47) | LTA4HFFAR1EPHX2TSHRL3MBTL1 | |
| SCHEMBL919392 | 0.80 | LTA4H (0.59) | LTA4HTSHRL3MBTL1MEN1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 182 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10772874-B2 | Compounds and compositions for the inhibition of NAMPT | VALO HEALTH, INC. | 2020-09-15 | — | — | US | claimed |
| US-10272072-B2 | Compounds and compositions for the inhibition of NAMPT | FORMA TM, LLC (US) | 2019-04-30 | — | — | US | claimed |
| US-20170368039-A1 | NOVEL COMPOUNDS AND COMPOSITIONS FOR THE INHIBITION OF NAMPT | FORMA TM, LLC (US) | 2017-12-28 | — | — | US | claimed |
| EP-2504324-B1 | SULTAM DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2015-02-25 | — | — | EP | claimed |
| US-20140294805-A1 | NOVEL COMPOUNDS AND COMPOSITIONS FOR THE INHIBITION OF NAMPT | VALO EARLY DISCOVERY, INC. | 2014-10-02 | — | — | US | claimed |
| CN-103917094-A | Glucosylceramide synthase inhibitors | GENZYME CORP | 2014-07-09 | — | — | CN | claimed |
| EP-2486005-B1 | PYRROLIDINE GPR40 MODULATORS | BRISTOL MYERS SQUIBB CO (US) | 2014-06-18 | — | — | EP | claimed |
| CN-103384668-A | Novel compounds and compositions for inhibiting NAMPT | FORMA THERAPEUTICS INC | 2013-11-06 | — | — | CN | claimed |
| EP-2611804-A1 | NOVEL COMPOUNDS AND COMPOSITIONS FOR THE INHIBITION OF NAMPT | Forma TM, LLC. (US) | 2013-07-10 | — | — | EP | claimed |
| CN-103119030-A | Matrix metalloproteinase inhibitors | RANBAXY LAB LTD | 2013-05-22 | — | — | CN | claimed |
| EP-0058505-A1 | Preparation of esters containing an alpha-cyano group in the alcohol portion of the esters | FMC Corporation (US) | 1982-08-25 | — | — | EP | claimed |
| US-4344960-A | Combating insects and acarids with 3-(2-chloro-3,3,4,4,4-pentafluoro-1-butenyl)-2,2-dimethyl-cyclopropanecarboxylic acid esters | BAYER AKTIENGESELLSCHAFT (DE) | 1982-08-17 | — | — | US | claimed |
| US-4323685-A | Preparation of esters | FMC CORPORATION (US) | 1982-04-06 | — | — | US | claimed |
| US-4322534-A | Preparation of esters | FMC CORPORATION (US) | 1982-03-30 | — | — | US | claimed |
| US-4322535-A | REACTION OF AN ACYL HALIDE, ALDEHYDE, AND CYANIDE SALT USING A CATALYTIC AMPHOTERIC SURFACTANT OF AN AMINO ALKYLSULFONATE | FMC CORPORATION (US) | 1982-03-30 | — | — | US | claimed |
| US-4318922-A | INSECTICIDES, ACARICIDES | BAYER AKTIENGESELLSCHAFT (DE) | 1982-03-09 | — | — | US | claimed |
| US-4317834-A | Combating arthropods with fluorine-substituted spiro-carboxylic acid benzyl esters | BAYER AKTIENGESELLSCHAFT (DE) | 1982-03-02 | — | — | US | claimed |
| EP-0043492-A2 | 1-Aryl-cyclopropane-1-carboxylic-acid esters, their preparation and their use as insecticides | BAYER AG (DE) | 1982-01-13 | — | — | EP | claimed |
| EP-0040742-A1 | 3-(Chloro-3,3,4,4,4-pentafluoro-1-butenyl)-2,2-dimethylcyclopropanecarboxylic acid esters, process for their preparation and their use in insecticides | BAYER AG (DE) | 1981-12-02 | — | — | EP | claimed |
| US-4279923-A | Combating pests with 3-(2,3-dichloro-3,3-difluoro-prop-1-en-1-yl)-2,2-dimethyl-cyclo-propanecarboxylic acid fluoro-benzyl esters | BAYER AKTIENGESELLSCHAFT (DE) | 1981-07-21 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170368039-A1 | NOVEL COMPOUNDS AND COMPOSITIONS FOR THE INHIBITION OF NAMPT | NAMPT, NNMT, NQO1 | SOS1 4521/4885HSPB1 4246/4885LTA4H 2761/4885 |
| US-20140294805-A1 | NOVEL COMPOUNDS AND COMPOSITIONS FOR THE INHIBITION OF NAMPT | NAMPT, NNMT, NQO1 | SOS1 4521/4885HSPB1 4246/4885LTA4H 2761/4885 |
| US-10772874-B2 | Compounds and compositions for the inhibition of NAMPT | NAMPT, NNMT, NQO1 | SOS1 4385/4885HSPB1 4446/4885LTA4H 2984/4885 |
| US-10272072-B2 | Compounds and compositions for the inhibition of NAMPT | NAMPT, NNMT, NQO1 | SOS1 4385/4885HSPB1 4446/4885LTA4H 2984/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.