Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 20/20 | 1.00 |
| ▸ | CNR1 | P21554 | 1/20 | 0.71 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15788857 | 0.93 | CNR2 (1.00) | CNR2 | |
| SCHEMBL15774955 | 0.85 | CNR2 (1.00) | CNR2 | |
| SCHEMBL15788855 | 0.85 | CNR2 (1.00) | CNR2CNR1 | |
| SCHEMBL15774849 | 0.85 | CNR2 (1.00) | CNR2 | |
| SCHEMBL14226283 | 0.84 | CNR2 (1.00) | CNR2 | |
| SCHEMBL17207913 | 0.83 | CNR2 (1.00) | CNR2CNR1 | |
| SCHEMBL15774521 | 0.83 | CNR2 (1.00) | CNR2CNR1 | |
| SCHEMBL15788892 | 0.81 | CNR2 (1.00) | CNR2 | |
| SCHEMBL15788902 | 0.81 | CNR2 (1.00) | CNR2 | |
| SCHEMBL21609535 | 0.80 | CNR2 (0.77) | CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3357918-A1 | NOVEL PYRIDINE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2018-08-08 | — | — | EP | claimed |
| US-9522886-B2 | Pyridine derivatives | HOFFMANN-LA ROCHE INC. (US) | 2016-12-20 | — | — | US | claimed |
| US-20150307452-A1 | NOVEL PYRIDINE DERIVATIVES | HOFFMANN-LA ROCHE INC. (US) | 2015-10-29 | — | — | US | claimed |
| EP-2928881-A1 | NOVEL PYRIDINE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2015-10-14 | — | — | EP | claimed |
| WO-2014086705-A1 | NOVEL PYRIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2014-06-12 | — | — | WO | claimed |
| EP-3357918-A1 | NOVEL PYRIDINE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2018-08-08 | — | — | EP | disclosed |
| EP-3357918-A1 | NOVEL PYRIDINE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2018-08-08 | — | — | EP | disclosed |
| EP-2928881-B1 | NOVEL PYRIDINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2018-03-14 | — | — | EP | disclosed |
| EP-2928881-B1 | NOVEL PYRIDINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2018-03-14 | — | — | EP | disclosed |
| US-9522886-B2 | Pyridine derivatives | HOFFMANN-LA ROCHE INC. (US) | 2016-12-20 | — | — | US | disclosed |
| US-9522886-B2 | Pyridine derivatives | HOFFMANN-LA ROCHE INC. (US) | 2016-12-20 | — | — | US | disclosed |
| US-9522886-B2 | Pyridine derivatives | HOFFMANN-LA ROCHE INC. (US) | 2016-12-20 | — | — | US | disclosed |
| US-20150307452-A1 | NOVEL PYRIDINE DERIVATIVES | HOFFMANN-LA ROCHE INC. (US) | 2015-10-29 | — | — | US | disclosed |
| US-20150307452-A1 | NOVEL PYRIDINE DERIVATIVES | HOFFMANN-LA ROCHE INC. (US) | 2015-10-29 | — | — | US | disclosed |
| US-20150307452-A1 | NOVEL PYRIDINE DERIVATIVES | HOFFMANN-LA ROCHE INC. (US) | 2015-10-29 | — | — | US | disclosed |
| EP-2928881-A1 | NOVEL PYRIDINE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2015-10-14 | — | — | EP | disclosed |
| WO-2014086705-A1 | NOVEL PYRIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2014-06-12 | — | — | WO | disclosed |
| WO-2014086705-A1 | NOVEL PYRIDINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2014-06-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150307452-A1 | NOVEL PYRIDINE DERIVATIVES | NDUFS6, NDUFS3, NDUFV2 | CNR2 23/4885CNR1 17/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.