NDUFS6 — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Auraptene (SCHEMBL2535029)	1.00	5/20
Auraptene (SCHEMBL2535034)	1.00	5/20
SCHEMBL8491443	0.56	4/20
SCHEMBL8489900	0.52	4/20
SCHEMBL8489907	0.52	4/20
SCHEMBL8489902	0.51	4/20
SCHEMBL8489908	0.51	4/20
SCHEMBL8491154	0.51	4/20
SCHEMBL8491160	0.51	4/20
SCHEMBL8491619	0.50	4/20
SCHEMBL8491624	0.50	4/20
SCHEMBL8491634	0.50	4/20
7-Prenyloxycoumarin (SCHEMBL4898255)	0.79	3/20
SCHEMBL712741	0.57	3/20
Geiparvarin (SCHEMBL2532495)	0.56	3/20
SCHEMBL6267768	0.55	3/20
SCHEMBL1095981	0.55	3/20
SCHEMBL4293165	0.55	3/20
SCHEMBL8490928	0.53	3/20
SCHEMBL8490937	0.53	3/20

Clinical trials — most relevant to NDUFS6 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Phase III Trial of Coenzyme Q10 in Mitochondrial Disease	PHASE3	COMPLETED
A Study of the Efficacy and Safety of MT1621 in Thymidine Kinase 2 (TK2) Deficiency (Treatment naïve)	PHASE3	WITHDRAWN
Coenzyme Q10 as a Symptomatic Treatment in Parkinson's Disease	PHASE3	COMPLETED
Mitochondrial Dysfunction in the Pathophysiology and Treatment of Bipolar Disorder	PHASE2	WITHDRAWN
A Study of Bezafibrate in Mitochondrial Myopathy	PHASE2	COMPLETED
Nicotinamide Riboside on Mitochondrial Function in Li-Fraumeni Syndrome	PHASE1/PHASE2	COMPLETED
Trial of Nicotinamide Riboside and Co-enzyme Q10 in Chronic Kidney Disease	PHASE2	COMPLETED
Parkinson's Disease Treatment With Coenzyme Q10	PHASE2	COMPLETED
Does Clinical Treatment of Mitochondrial Dysfunction Impact Autism Spectrum Disorder (ASD)?	PHASE1	UNKNOWN
Genomic Profiling of Mitochondrial Disease - Imaging Analysis for Precise Mitochondrial Medicine	nan	COMPLETED
Tissue Sample Study for Mitochondrial Disorders	nan	ENROLLING_BY_INVITATION
Evaluation of Impact of Disease and Visual Disability on Quality of Life and Loss of Independence of Patients Living in France With Leber's Hereditary Optic Neuropathy (LHON) Through Qualitative and Quantitative Data Collection	nan	COMPLETED
Mitoquines in COPD	nan	UNKNOWN
North American Mitochondrial Disease Consortium Patient Registry and Biorepository (NAMDC)	nan	RECRUITING
The Genetics of Diabetes in Southern California Chinese Americans	nan	WITHDRAWN
Gastrointestinal Dysfunction in Children Affected With Mitochondrial Disorders	nan	COMPLETED
MITOMICS : a Multi-OMICS Approach for the Diagnosis of Mitochondrial Diseases	nan	RECRUITING
Effect of Subtle Energy Transmission and Tao Calligraphy Mindfulness Practice on Mitochondrial DNA in Peripheral Blood Leukocytes	nan	NOT_YET_RECRUITING
The Natural History of Mitochondrial Diseases	nan	RECRUITING
Impact of Iron Deficiency and Its Correction on Mitochondrial Metabolism of the Cardiomyocyte (MitoCardioFer)	nan	COMPLETED
Natural History in Primary Mitochondrial Myopathies	nan	RECRUITING
Natural History Study of FDXR Mutation-related Mitochondriopathy	nan	COMPLETED
Drug Repurposing for Mitochondrial Disorders Using iPSCs Derived Neural Cells	nan	RECRUITING
GDF-15 as a Biomarker for Mitochondrial Disease	nan	COMPLETED
A Study Into the Underlying Biochemical Pathways Involved in Parkinson's Disease, Such as Mitochondrial (Cellular Powerhouse) Dysfunction	nan	COMPLETED
Diagnostic Odyssey Survey 2	nan	COMPLETED
Effect of Diaphragm Stimulation During Surgery	nan	COMPLETED
Pharmacokinetic Study on Three Formulations of Coenzyme Q10 With Different Carriers	nan	UNKNOWN
Mitochondrial Dysfunctions Driving Insulin Resistance	nan	COMPLETED
Human Mitochondrial Stress-driven Obesity Resistance	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a NDUFS6 binder may also engage these)

Protein	Name	Similarity
Q0MQH6	—	1.000	Q0MQH6 →
Q0MQH5	—	1.000	Q0MQH5 →
Q0MQH7	—	1.000	Q0MQH7 →
P52503	—	0.997	P52503 →
Q4R5X8	—	0.994	Q4R5X8 →
P23934	—	0.986	P23934 →
P52504	—	0.978	P52504 →
Q9M9M6	—	0.956	Q9M9M6 →
P09925	—	0.954	P09925 →
Q9QXU2	—	0.953	Q9QXU2 →
Q9D1N9	—	0.951	Q9D1N9 →
P82664	—	0.950	P82664 →
Q15526	—	0.950	Q15526 →
Q5XIF3	—	0.949	Q5XIF3 →
Q5RFM3	—	0.948	Q5RFM3 →
Q08BI9	—	0.948	Q08BI9 →
Q8BW10	—	0.948	Q8BW10 →
Q5RBB3	—	0.947	Q5RBB3 →
P82917	—	0.947	P82917 →
Q800L1	—	0.947	Q800L1 →
TIMM44	Mitochondrial import inner membrane translocase subunit TIM44	0.947	landscape →
Q9Y3D5	—	0.947	Q9Y3D5 →
P82919	—	0.947	P82919 →
Q5SPH9	—	0.947	Q5SPH9 →
E9Q4Z2	—	0.946	E9Q4Z2 →
Q86XE3	—	0.946	Q86XE3 →
MRPS18A	Large ribosomal subunit protein mL66	0.945	landscape →
P82670	—	0.945	P82670 →
Q4R537	—	0.945	Q4R537 →
Q8BML1	—	0.944	Q8BML1 →