Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | GRM5 | P41594 | 3/20 | 0.40 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.38 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30521933 | 1.00 | APP (0.43) | APPALDH1A1HPGDADORA2ATSHR | |
| SCHEMBL15776051 | 0.85 | ALDH1A1 (0.42) | ALDH1A1HPGDTSHRNPC1CYP1A2 | |
| SCHEMBL22271110 | 0.85 | GRM5 (0.37) | KDM4EGRM5LRRK2 | |
| SCHEMBL15775600 | 0.85 | NPC1 (0.47) | NPC1GRM5 | |
| SCHEMBL15775456 | 0.85 | APP (0.45) | APPALDH1A1HPGDKDM4ENPC1 | |
| SCHEMBL15775708 | 0.83 | MAOB (0.57) | ALDH1A1HPGDKDM4EMEN1NPC1 | |
| SCHEMBL15775434 | 0.81 | ALDH1A1 (0.50) | APPALDH1A1HPGDKDM4EMEN1 | |
| SCHEMBL15775234 | 0.81 | CYP3A4 (0.44) | CYP3A4GRM5 | |
| SCHEMBL29141348 | 0.79 | APP (0.48) | APPADORA2ATSHRMAPTGRM5 | |
| SCHEMBL18611 | 0.78 | LRRK2 (0.46) | ALDH1A1HPGDTSHRKDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014087165-A1 | TANKYRASE INHIBITORS | UNIVERSITY OF BATH (GB) | 2014-06-12 | — | — | WO | disclosed |