Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 3/20 | 0.57 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.45 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.45 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.45 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | FFAR1 | O14842 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.43 |
| ▸ | AR | P10275 | 1/20 | 0.43 |
| ▸ | FDFT1 | P37268 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15775225 | 0.83 | APP (0.43) | CYP3A4CYP1A2CYP2C19MAPTHSD17B10 | |
| SCHEMBL30521933 | 0.83 | APP (0.43) | CYP3A4CYP1A2CYP2C19MAPTHSD17B10 | |
| SCHEMBL15775434 | 0.81 | ALDH1A1 (0.50) | MAPTRAB9ASMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL14786201 | 0.78 | MAOB (0.71) | MAOBPTPN1PTPN6PTPN11FFAR1 | |
| SCHEMBL15775600 | 0.76 | NPC1 (0.47) | MAOBFFAR1RAB9AMAOANPC1 | |
| SCHEMBL22271110 | 0.76 | GRM5 (0.37) | MAOBKDM4E | |
| SCHEMBL15775456 | 0.76 | APP (0.45) | CYP3A4CYP1A2CYP2C19MAPTRAB9A | |
| SCHEMBL15776051 | 0.76 | ALDH1A1 (0.42) | CYP3A4CYP1A2CYP2C19RAB9ASMN1; SMN2 | |
| SCHEMBL403151 | 0.75 | MAOB (1.00) | MAOBLMNACYP1A2PTGS1SLC6A2 | |
| SCHEMBL4034458 | 0.74 | MAOB (0.51) | MAOBIMPDH2CYP3A4RAB9AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014087165-A1 | TANKYRASE INHIBITORS | UNIVERSITY OF BATH (GB) | 2014-06-12 | — | — | WO | disclosed |