Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.38 |
| ▸ | ADK | P55263 | 3/20 | 0.38 |
| ▸ | GRM5 | P41594 | 2/20 | 0.37 |
| ▸ | PTGES | O14684 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | SRC | P12931 | 1/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15775225 | 0.85 | APP (0.43) | NPC1GRM5 | |
| SCHEMBL30521933 | 0.85 | APP (0.43) | NPC1GRM5 | |
| SCHEMBL15775456 | 0.84 | APP (0.45) | NPC1RAB9AADK | |
| SCHEMBL15776051 | 0.84 | ALDH1A1 (0.42) | NPC1RAB9AADKGRM5KCNH2 | |
| SCHEMBL22271110 | 0.84 | GRM5 (0.37) | GRM5MAOBCYP11B2 | |
| SCHEMBL15775434 | 0.80 | ALDH1A1 (0.50) | NPC1RAB9AADKKCNH2 | |
| SCHEMBL15775234 | 0.80 | CYP3A4 (0.44) | GRM5 | |
| SCHEMBL15775708 | 0.76 | MAOB (0.57) | NPC1RAB9AFFAR1MAOAMAOB | |
| SCHEMBL18087838 | 0.75 | KCNH2 (0.43) | NPC1RAB9AFFAR1GRM5KCNH2 | |
| SCHEMBL18611 | 0.74 | LRRK2 (0.46) | NPC1RAB9ACYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014087165-A1 | TANKYRASE INHIBITORS | UNIVERSITY OF BATH (GB) | 2014-06-12 | — | — | WO | disclosed |