Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | APP | P05067 | 2/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.38 |
| ▸ | ADK | P55263 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | CRHBP | P24387 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4765899 | 0.88 | MAPT (0.47) | ALDH1A1MAPTPOLBGAAAPP | |
| SCHEMBL15776051 | 0.83 | ALDH1A1 (0.42) | ALDH1A1POLBKCNH2NPC1RAB9A | |
| SCHEMBL15775225 | 0.81 | APP (0.43) | ALDH1A1MAPTAPPNPC1SMN1; SMN2 | |
| SCHEMBL30521933 | 0.81 | APP (0.43) | ALDH1A1MAPTAPPNPC1SMN1; SMN2 | |
| SCHEMBL15775708 | 0.81 | MAOB (0.57) | ALDH1A1MAPTPOLBGAANPC1 | |
| SCHEMBL15775456 | 0.80 | APP (0.45) | ALDH1A1MAPTPOLBAPPNPC1 | |
| SCHEMBL15775600 | 0.80 | NPC1 (0.47) | KCNH2NPC1RAB9AADK | |
| SCHEMBL22271110 | 0.80 | GRM5 (0.37) | KDM4E | |
| SCHEMBL28368555 | 0.78 | POLB (0.57) | ALDH1A1MAPTPOLBGAAAPP | |
| SCHEMBL15775234 | 0.77 | CYP3A4 (0.44) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014087165-A1 | TANKYRASE INHIBITORS | UNIVERSITY OF BATH (GB) | 2014-06-12 | — | — | WO | disclosed |