Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNKS | O95271 | 13/20 | 0.63 |
| ▸ | TNKS2 | Q9H2K2 | 13/20 | 0.63 |
| ▸ | PARP1 | P09874 | 10/20 | 0.63 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.50 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.50 |
| ▸ | PARP2 | Q9UGN5 | 2/20 | 0.49 |
| ▸ | AR | P10275 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.42 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.41 |
| ▸ | GCGR | P47871 | 1/20 | 0.41 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.41 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.41 |
| ▸ | GUSB | P08236 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15775567 | 0.88 | PARP1 (0.61) | TNKSTNKS2PARP1ADORA2AGUSB | |
| SCHEMBL15775644 | 0.87 | TNKS (0.60) | TNKSTNKS2PARP1GUSB | |
| SCHEMBL15775482 | 0.86 | PARP1 (0.63) | TNKSTNKS2PARP1MAPTADORA1 | |
| SCHEMBL15775320 | 0.86 | TNKS (0.63) | TNKSTNKS2PARP1PARP2GUSB | |
| SCHEMBL15775381 | 0.86 | TNKS (0.63) | TNKSTNKS2PARP1PARP2 | |
| SCHEMBL15775691 | 0.86 | TNKS (0.63) | TNKSTNKS2PARP1 | |
| SCHEMBL15775249 | 0.83 | TNKS (0.63) | TNKSTNKS2PARP1CYP1A1CYP1B1 | |
| SCHEMBL15775430 | 0.82 | TNKS (0.65) | TNKSTNKS2PARP1PARP2 | |
| SCHEMBL1387250 | 0.81 | TNKS (0.66) | TNKSTNKS2PARP1PARP2MAPT | |
| SCHEMBL15775408 | 0.80 | TNKS (0.65) | TNKSTNKS2PARP1CYP1A1CYP1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014087165-A1 | TANKYRASE INHIBITORS | UNIVERSITY OF BATH (GB) | 2014-06-12 | — | — | WO | disclosed |