Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNKS | O95271 | 10/20 | 0.60 |
| ▸ | PARP1 | P09874 | 10/20 | 0.60 |
| ▸ | TNKS2 | Q9H2K2 | 10/20 | 0.60 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.47 |
| ▸ | PIM1 | P11309 | 1/20 | 0.47 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.47 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.47 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.47 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.47 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.47 |
| ▸ | GUSB | P08236 | 2/20 | 0.47 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.45 |
| ▸ | GSK3B | P49841 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | RNASEH1 | O60930 | 1/20 | 0.44 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.44 |
| ▸ | FEN1 | P39748 | 1/20 | 0.44 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15775567 | 0.89 | PARP1 (0.61) | TNKSPARP1TNKS2GUSBADORA2B | |
| SCHEMBL15775241 | 0.87 | TNKS (0.63) | TNKSPARP1TNKS2GUSB | |
| SCHEMBL15775482 | 0.87 | PARP1 (0.63) | TNKSPARP1TNKS2GUSBADORA2B | |
| SCHEMBL15775381 | 0.87 | TNKS (0.63) | TNKSPARP1TNKS2KDM4E | |
| SCHEMBL15775320 | 0.87 | TNKS (0.63) | TNKSPARP1TNKS2GUSB | |
| SCHEMBL15775691 | 0.87 | TNKS (0.63) | TNKSPARP1TNKS2KDM4E | |
| SCHEMBL15775430 | 0.83 | TNKS (0.65) | TNKSPARP1TNKS2 | |
| SCHEMBL1387250 | 0.82 | TNKS (0.66) | TNKSPARP1TNKS2GUSBADORA2B | |
| SCHEMBL15775475 | 0.81 | TNKS (0.60) | TNKSPARP1TNKS2MAP4K4PIM1 | |
| SCHEMBL15775406 | 0.78 | TNKS (0.63) | TNKSPARP1TNKS2DYRK1AGUSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014087165-A1 | TANKYRASE INHIBITORS | UNIVERSITY OF BATH (GB) | 2014-06-12 | — | — | WO | disclosed |