Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNKS | O95271 | 12/20 | 0.63 |
| ▸ | TNKS2 | Q9H2K2 | 12/20 | 0.63 |
| ▸ | PARP1 | P09874 | 9/20 | 0.63 |
| ▸ | PARP2 | Q9UGN5 | 3/20 | 0.50 |
| ▸ | PLA2G7 | Q13093 | 2/20 | 0.44 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15775567 | 0.88 | PARP1 (0.61) | TNKSTNKS2PARP1KDM4E | |
| SCHEMBL15775644 | 0.87 | TNKS (0.60) | TNKSTNKS2PARP1KDM4E | |
| SCHEMBL15775241 | 0.86 | TNKS (0.63) | TNKSTNKS2PARP1PARP2 | |
| SCHEMBL15775482 | 0.86 | PARP1 (0.63) | TNKSTNKS2PARP1KDM4ENPC1 | |
| SCHEMBL15775691 | 0.86 | TNKS (0.63) | TNKSTNKS2PARP1PLA2G7KDM4E | |
| SCHEMBL15775320 | 0.86 | TNKS (0.63) | TNKSTNKS2PARP1PARP2PLA2G7 | |
| SCHEMBL15775430 | 0.85 | TNKS (0.65) | TNKSTNKS2PARP1PARP2RAB9A | |
| SCHEMBL15775472 | 0.83 | TNKS (0.63) | TNKSTNKS2PARP1PARP2KDM4E | |
| SCHEMBL1387250 | 0.81 | TNKS (0.66) | TNKSTNKS2PARP1PARP2NPC1 | |
| SCHEMBL15775468 | 0.81 | TNKS (0.64) | TNKSTNKS2PARP1PARP2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014087165-A1 | TANKYRASE INHIBITORS | UNIVERSITY OF BATH (GB) | 2014-06-12 | — | — | WO | disclosed |