Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 1/20 | 0.52 |
| ▸ | PHGDH | O43175 | 1/20 | 0.52 |
| ▸ | MGLL | Q99685 | 1/20 | 0.52 |
| ▸ | CA12 | O43570 | 1/20 | 0.52 |
| ▸ | CA1 | P00915 | 1/20 | 0.52 |
| ▸ | CA2 | P00918 | 1/20 | 0.52 |
| ▸ | CA9 | Q16790 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8661742 | 0.83 | FAAH (0.55) | FAAHPHGDHMGLLCA12CA1 | |
| SCHEMBL25137386 | 0.83 | FAAH (0.64) | FAAHPHGDHMGLLCA12CA1 | |
| SCHEMBL7993986 | 0.79 | FAAH (0.59) | FAAHPHGDHMGLLCA12CA1 | |
| SCHEMBL2232383 | 0.74 | ALDH1A1 (0.60) | FAAHPHGDHMGLLCA12CA1 | |
| SCHEMBL8848450 | 0.73 | FAAH (0.64) | FAAHPHGDHMGLLCA12CA1 | |
| SCHEMBL31410778 | 0.73 | ALDH1A1 (0.58) | FAAHPHGDHMGLLCA12CA1 | |
| SCHEMBL14273119 | 0.72 | FAAH (0.47) | FAAHPHGDHMGLLCA12CA1 | |
| SCHEMBL5961342 | 0.72 | FAAH (0.61) | FAAHPHGDHMGLLCA12CA1 | |
| SCHEMBL7814241 | 0.71 | ALDH1A1 (0.50) | FAAHPHGDHMGLLCA12CA1 | |
| SCHEMBL1224111 | 0.70 | FAAH (0.59) | FAAHPHGDHMGLLCA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014086478-A1 | INHIBITORS OF MALT1 PROTEASE | Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) (DE) | 2014-06-12 | — | — | WO | disclosed |