Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNKS | O95271 | 5/20 | 0.59 |
| ▸ | PARP1 | P09874 | 3/20 | 0.59 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.58 |
| ▸ | CDK1 | P06493 | 1/20 | 0.58 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.58 |
| ▸ | GSK3A | P49840 | 1/20 | 0.58 |
| ▸ | GSK3B | P49841 | 1/20 | 0.58 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.58 |
| ▸ | TNKS2 | Q9H2K2 | 4/20 | 0.54 |
| ▸ | WNT3A | P56704 | 1/20 | 0.54 |
| ▸ | MAOB | P27338 | 1/20 | 0.45 |
| ▸ | SYK | P43405 | 1/20 | 0.45 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.45 |
| ▸ | PARP2 | Q9UGN5 | 2/20 | 0.44 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.44 |
| ▸ | TOP1 | P11387 | 1/20 | 0.42 |
| ▸ | SCN2A | Q99250 | 2/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.42 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8602417 | 0.83 | ADORA2A (0.59) | TNKSPARP1CCNB2CDK1CCNB1 | |
| SCHEMBL15775268 | 0.82 | CCNB2 (0.55) | TNKSPARP1CCNB2CDK1CCNB1 | |
| SCHEMBL15775696 | 0.82 | TNKS (0.57) | TNKSPARP1CCNB2CDK1CCNB1 | |
| SCHEMBL15775722 | 0.82 | CCNB2 (0.55) | TNKSPARP1CCNB2CDK1CCNB1 | |
| SCHEMBL15775563 | 0.82 | PARP1 (0.56) | TNKSPARP1CCNB2CDK1CCNB1 | |
| SCHEMBL15775264 | 0.82 | RIPK1 (0.52) | TNKSPARP1TNKS2PARP2ADORA2A | |
| SCHEMBL4773542 | 0.78 | PARP1 (0.59) | TNKSPARP1CCNB2CDK1CCNB1 | |
| SCHEMBL4763725 | 0.77 | TNKS (0.64) | TNKSPARP1TNKS2WNT3AMAOB | |
| SCHEMBL15775421 | 0.75 | TNKS (0.73) | TNKSPARP1TNKS2WNT3APARP2 | |
| SCHEMBL12385912 | 0.74 | PARP1 (0.51) | TNKSPARP1TNKS2PARP2NPY5R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014087165-A1 | TANKYRASE INHIBITORS | UNIVERSITY OF BATH (GB) | 2014-06-12 | — | — | WO | disclosed |