Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 2/20 | 0.56 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.55 |
| ▸ | CDK1 | P06493 | 1/20 | 0.55 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.55 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.55 |
| ▸ | TNKS | O95271 | 2/20 | 0.51 |
| ▸ | GUSB | P08236 | 1/20 | 0.51 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.51 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.51 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.44 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.44 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.43 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8602417 | 0.86 | ADORA2A (0.59) | PARP1CCNB2CDK1CCNB1CCNB3 | |
| SCHEMBL15775696 | 0.85 | TNKS (0.57) | PARP1CCNB2CDK1CCNB1CCNB3 | |
| SCHEMBL15775722 | 0.85 | CCNB2 (0.55) | PARP1CCNB2CDK1CCNB1CCNB3 | |
| SCHEMBL15775264 | 0.85 | RIPK1 (0.52) | PARP1TNKSTNKS2PARP2KDM4E | |
| SCHEMBL15775268 | 0.85 | CCNB2 (0.55) | PARP1CCNB2CDK1CCNB1CCNB3 | |
| SCHEMBL4773542 | 0.82 | PARP1 (0.59) | PARP1CCNB2CDK1CCNB1CCNB3 | |
| SCHEMBL15775369 | 0.82 | TNKS (0.59) | PARP1CCNB2CDK1CCNB1CCNB3 | |
| SCHEMBL6648545 | 0.78 | PARP1 (0.47) | PARP1TNKSGUSBTNKS2PARP2 | |
| SCHEMBL12385912 | 0.78 | PARP1 (0.51) | PARP1TNKSTNKS2PARP2KDM4E | |
| SCHEMBL13495429 | 0.77 | PIK3CD (0.53) | PARP1TNKSTNKS2PARP2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014087165-A1 | TANKYRASE INHIBITORS | UNIVERSITY OF BATH (GB) | 2014-06-12 | — | — | WO | disclosed |