Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNKS | O95271 | 5/20 | 0.57 |
| ▸ | TNKS2 | Q9H2K2 | 3/20 | 0.57 |
| ▸ | PARP1 | P09874 | 3/20 | 0.56 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.55 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.55 |
| ▸ | CDK1 | P06493 | 1/20 | 0.55 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.55 |
| ▸ | GSK3A | P49840 | 1/20 | 0.55 |
| ▸ | GSK3B | P49841 | 1/20 | 0.55 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.55 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 3/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | CTSV | O60911 | 1/20 | 0.49 |
| ▸ | CTSL | P07711 | 1/20 | 0.49 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.48 |
| ▸ | ACVR1 | Q04771 | 2/20 | 0.47 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.44 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8602417 | 0.86 | ADORA2A (0.59) | TNKSTNKS2PARP1CDK5CCNB2 | |
| SCHEMBL15775722 | 0.85 | CCNB2 (0.55) | TNKSTNKS2PARP1CDK5CCNB2 | |
| SCHEMBL15775563 | 0.85 | PARP1 (0.56) | TNKSTNKS2PARP1CCNB2CDK1 | |
| SCHEMBL15775268 | 0.85 | CCNB2 (0.55) | TNKSTNKS2PARP1CCNB2CDK1 | |
| SCHEMBL15775264 | 0.85 | RIPK1 (0.52) | TNKSTNKS2PARP1HPGDRAB9A | |
| SCHEMBL4773542 | 0.85 | PARP1 (0.59) | TNKSTNKS2PARP1CDK5CCNB2 | |
| SCHEMBL15775369 | 0.82 | TNKS (0.59) | TNKSTNKS2PARP1CCNB2CDK1 | |
| SCHEMBL348483 | 0.82 | PTGER3 (0.47) | TNKSTNKS2PARP1HPGDRAB9A | |
| Hydrochloric Acid SCHEMBL1646954 | 0.81 | PTGER3 (0.46) | TNKSTNKS2PARP1HPGDRAB9A | |
| SCHEMBL7395879 | 0.78 | GAA (0.53) | TNKS2PARP1RAB9AATAD2ACVR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014087165-A1 | TANKYRASE INHIBITORS | UNIVERSITY OF BATH (GB) | 2014-06-12 | — | — | WO | disclosed |