Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNKS | O95271 | 3/20 | 0.46 |
| ▸ | PARP1 | P09874 | 3/20 | 0.46 |
| ▸ | TNKS2 | Q9H2K2 | 3/20 | 0.46 |
| ▸ | GAA | P10253 | 5/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | HPGD | P15428 | 4/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2823766 | 0.80 | ALDH1A1 (0.64) | TNKSPARP1TNKS2GAARAB9A | |
| SCHEMBL2744822 | 0.76 | NPC1 (0.61) | TNKSPARP1TNKS2GAARAB9A | |
| SCHEMBL15775394 | 0.74 | TNKS (0.68) | TNKSPARP1TNKS2GAARAB9A | |
| SCHEMBL8618963 | 0.74 | ALDH1A1 (0.56) | TNKSPARP1TNKS2GAARAB9A | |
| SCHEMBL15775281 | 0.73 | KDM4C (0.56) | TNKSPARP1TNKS2GAARAB9A | |
| SCHEMBL3497007 | 0.72 | RXFP1 (0.69) | TNKSPARP1TNKS2GAAALDH1A1 | |
| SCHEMBL11309014 | 0.72 | ALDH1A1 (0.59) | TNKSPARP1TNKS2GAARAB9A | |
| SCHEMBL8620408 | 0.70 | NR1I3 (0.54) | TNKSPARP1TNKS2GAARAB9A | |
| SCHEMBL24392021 | 0.70 | PDE3B (0.63) | TNKSTNKS2RAB9ANPC1ALDH1A1 | |
| SCHEMBL29588668 | 0.70 | PDE3B (0.63) | TNKSTNKS2RAB9ANPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014087165-A1 | TANKYRASE INHIBITORS | UNIVERSITY OF BATH (GB) | 2014-06-12 | — | — | WO | disclosed |