SCHEMBL15775281

SCHEMBL15775281

O=c1nc(-c2ccccc2)[nH]c2ccncc12

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4C Q9H3R0 2/20 0.56
PARP1 P09874 3/20 0.51
ACHE P22303 1/20 0.49
HPGD P15428 3/20 0.48
ALDH1A1 P00352 4/20 0.48
MAPT P10636 4/20 0.48
ALOX15 P16050 1/20 0.48
HSD17B10 Q99714 1/20 0.48
APOBEC3G Q9HC16 1/20 0.48
GAA P10253 2/20 0.47
POLB P06746 2/20 0.47
RXFP1 Q9HBX9 1/20 0.47
GSK3B P49841 1/20 0.47
MAPK13 O15264 2/20 0.46
RAF1 P04049 2/20 0.46
MAPK12 P53778 2/20 0.46
MAPK11 Q15759 2/20 0.46
MAPK14 Q16539 2/20 0.46
MAPK9 P45984 1/20 0.46
HTR6 P50406 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15775256 0.85 ACHE (0.49) KDM4CPARP1ACHEHPGDALDH1A1
SCHEMBL15775257 0.85 ALDH1A1 (0.60) PARP1HPGDALDH1A1MAPTHSD17B10
SCHEMBL2823766 0.82 ALDH1A1 (0.64) PARP1HPGDALDH1A1MAPTALOX15
SCHEMBL7280826 0.80 KDM4E (0.63) KDM4CHPGDALDH1A1MAPTGAA
SCHEMBL7127398 0.77 NPC1 (0.65) KDM4CHPGDALDH1A1MAPTALOX15
SCHEMBL8618963 0.76 ALDH1A1 (0.56) PARP1HPGDALDH1A1MAPTHSD17B10
SCHEMBL14344516 0.76 KDM4C (0.80) KDM4CPARP1HPGDALDH1A1MAPT
SCHEMBL10852378 0.74 NPC1 (0.61) KDM4CHPGDALDH1A1MAPTHSD17B10
SCHEMBL11309014 0.74 ALDH1A1 (0.59) PARP1HPGDALDH1A1MAPTHSD17B10
SCHEMBL3497007 0.74 RXFP1 (0.69) PARP1HPGDALDH1A1MAPTGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2014087165-A1 TANKYRASE INHIBITORS UNIVERSITY OF BATH (GB) 2014-06-12 WO disclosed