Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA9 | Q16790 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | RORC | P51449 | 6/20 | 0.49 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.46 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | CA3 | P07451 | 1/20 | 0.44 |
| ▸ | CA4 | P22748 | 1/20 | 0.44 |
| ▸ | CA6 | P23280 | 1/20 | 0.44 |
| ▸ | CA5A | P35218 | 1/20 | 0.44 |
| ▸ | CA7 | P43166 | 1/20 | 0.44 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.44 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15771952 | 0.83 | RORC (0.70) | CA9ALDH1A1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL15782089 | 0.83 | RORC (0.52) | RORCESR1PSEN1PSEN2APH1B | |
| SCHEMBL15780648 | 0.83 | RORC (0.55) | CYP2C9CYP2C19RORCESR1PSEN1 | |
| SCHEMBL15782088 | 0.81 | RORC (0.70) | RORCNR1H2MCL1 | |
| SCHEMBL7452453 | 0.80 | ALDH1A1 (0.47) | CA9ALDH1A1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL17174225 | 0.78 | C5AR1 (0.57) | CA9ALDH1A1CYP3A4NPSR1CA12 | |
| SCHEMBL15366970 | 0.72 | RORC (0.60) | ALDH1A1NPSR1RORCPSEN1PSEN2 | |
| SCHEMBL3472321 | 0.71 | APEX1 (0.59) | ALDH1A1CYP3A4ESR1LMNA | |
| SCHEMBL17852223 | 0.71 | RORC (0.43) | RORCESR1MCL1 | |
| SCHEMBL12706860 | 0.70 | RORC (0.50) | ALDH1A1RORCNR3C1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9382222-B2 | Benzyl sulfonamide derivatives as RORc modulators | GENENTECH, INC. (US) | 2016-07-05 | — | — | US | disclosed |
| US-20140163024-A1 | BENZYL SULFONAMIDE DERIVATIVES AS RORc MODULATORS | GENENTECH, INC. (US) | 2014-06-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140163024-A1 | BENZYL SULFONAMIDE DERIVATIVES AS RORc MODULATORS | RORC, RORA, RORB | CA9 1233/4885ALDH1A1 1145/4885CYP1A2 505/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.