Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | DPP4 | P27487 | 2/20 | 0.46 |
| ▸ | DPP9 | Q86TI2 | 2/20 | 0.46 |
| ▸ | SCN9A | Q15858 | 11/20 | 0.45 |
| ▸ | ERN1 | O75460 | 2/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | LANCL2 | Q9NS86 | 1/20 | 0.43 |
| ▸ | GNE | Q9Y223 | 1/20 | 0.43 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | BCR | P11274 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1580442 | 0.84 | POLB (0.47) | SCN9AERN1 | |
| SCHEMBL5671643 | 0.81 | KMO (0.50) | L3MBTL1ERN1 | |
| SCHEMBL1579578 | 0.79 | PRKD1 (0.48) | — | |
| SCHEMBL3075269 | 0.78 | GNE (0.55) | L3MBTL1DPP4DPP9SCN9AUSP2 | |
| SCHEMBL16065450 | 0.74 | ROCK2 (0.46) | SCN9A | |
| SCHEMBL1461593 | 0.72 | L3MBTL1 (0.86) | L3MBTL1SMN1; SMN2 | |
| SCHEMBL1579454 | 0.71 | PRKD1 (0.55) | — | |
| SCHEMBL15244228 | 0.71 | SCN9A (0.49) | DPP4DPP9SCN9AERN1LANCL2 | |
| SCHEMBL12753401 | 0.71 | HSD11B1 (0.58) | L3MBTL1DPP4DPP9SCN9AERN1 | |
| SCHEMBL1579600 | 0.70 | CNR1 (0.47) | L3MBTL1MAPK1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2310381-A1 | 2,4'-BIPYRIDINYL COMPOUNDS AS PROTEIN KINASE D INHIBITORS USEFUL FOR THE TREATMENT OF IA HEART FAILURE AND CANCER | Novartis AG (CH) | 2011-04-20 | — | — | EP | disclosed |
| WO-2009150230-A1 | 2,4'-BIPYRIDINYL COMPOUNDS AS PROTEIN KINASE D INHIBITORS USEFUL FOR THE TREATMENT OF IA HEART FAILURE AND CANCER | NOVARTIS AG (CH) | 2009-12-17 | — | — | WO | disclosed |