Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 5/20 | 0.39 |
| ▸ | PTGIR | P43119 | 4/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.36 |
| ▸ | PAOX | Q6QHF9 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | CKS1B | P61024 | 1/20 | 0.35 |
| ▸ | SKP1 | P63208 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15800096 | 1.00 | FAAH (0.39) | FAAHPTGIRHDAC1HDAC3HDAC2 | |
| SCHEMBL15800095 | 0.99 | FAAH (0.37) | FAAHPTGIRHDAC1HDAC3HDAC2 | |
| SCHEMBL363697 | 0.92 | PTGIR (0.47) | FAAHPTGIRKDM4EALDH1A1MAPT | |
| SCHEMBL362539 | 0.92 | PTGIR (0.47) | FAAHPTGIRKDM4EALDH1A1MAPT | |
| SCHEMBL361139 | 0.91 | PTGIR (0.45) | FAAHPTGIRKDM4EALDH1A1TDP1 | |
| SCHEMBL15800093 | 0.90 | NPC1 (0.36) | FAAHHDAC1HDAC3HDAC2HDAC8 | |
| SCHEMBL15800092 | 0.89 | FAAH (0.40) | FAAHHDAC1PAOXCYP3A4 | |
| SCHEMBL361581 | 0.88 | LTB4R (0.44) | FAAHPTGIRALDH1A1TDP1MAPT | |
| SCHEMBL363395 | 0.88 | LTB4R (0.44) | FAAHPTGIRALDH1A1TDP1MAPT | |
| SCHEMBL361701 | 0.87 | FAAH (0.53) | FAAHKDM4EALDH1A1LMNAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8754085-B2 | Pyrido[2,3-b]pyrazine compounds useful as IP receptor agonist | NOVARTIS AG (CH) | 2014-06-17 | — | — | US | disclosed |