Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 5/20 | 0.37 |
| ▸ | PTGIR | P43119 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.36 |
| ▸ | CKS1B | P61024 | 2/20 | 0.36 |
| ▸ | SKP1 | P63208 | 2/20 | 0.36 |
| ▸ | SKP2 | Q13309 | 2/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15800096 | 0.99 | FAAH (0.39) | FAAHPTGIRMAPTCYP3A4CYP2D6 | |
| SCHEMBL15800091 | 0.99 | FAAH (0.39) | FAAHPTGIRMAPTCYP3A4CYP2D6 | |
| SCHEMBL361139 | 0.92 | PTGIR (0.45) | FAAHPTGIRMAPTKDM4EALDH1A1 | |
| SCHEMBL363697 | 0.91 | PTGIR (0.47) | FAAHPTGIRMAPTKDM4EALDH1A1 | |
| SCHEMBL362539 | 0.91 | PTGIR (0.47) | FAAHPTGIRMAPTKDM4EALDH1A1 | |
| SCHEMBL15800093 | 0.89 | NPC1 (0.36) | FAAHMAPTCYP3A4HDAC1CNR1 | |
| SCHEMBL15800092 | 0.88 | FAAH (0.40) | FAAHCYP3A4HDAC1MAPK1 | |
| SCHEMBL361581 | 0.87 | LTB4R (0.44) | FAAHPTGIRMAPTALDH1A1 | |
| SCHEMBL363395 | 0.87 | LTB4R (0.44) | FAAHPTGIRMAPTALDH1A1 | |
| SCHEMBL360871 | 0.87 | SLC18A3 (0.37) | MAPTCYP3A4CYP2D6KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8754085-B2 | Pyrido[2,3-b]pyrazine compounds useful as IP receptor agonist | NOVARTIS AG (CH) | 2014-06-17 | — | — | US | disclosed |