Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.34 |
| ▸ | NAMPT | P43490 | 2/20 | 0.34 |
| ▸ | PAOX | Q6QHF9 | 1/20 | 0.34 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.34 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.34 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.34 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.34 |
| ▸ | REN | P00797 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL362351 | 0.91 | MAPK14 (0.40) | FAAHPKMMAPK14MAPK1CHRNA3 | |
| SCHEMBL15800093 | 0.90 | NPC1 (0.36) | FAAHHDAC1PKMPAOXREN | |
| SCHEMBL15800091 | 0.89 | FAAH (0.39) | FAAHHDAC1PAOXCYP3A4 | |
| SCHEMBL15800096 | 0.89 | FAAH (0.39) | FAAHHDAC1PAOXCYP3A4 | |
| SCHEMBL15111305 | 0.89 | PKM (0.41) | FAAHPKMMAPK14 | |
| SCHEMBL15800095 | 0.88 | FAAH (0.37) | FAAHHDAC1MAPK1CYP3A4 | |
| SCHEMBL15800094 | 0.87 | HSD17B10 (0.41) | HDAC1MAPK1CHRNA3CYP3A4 | |
| SCHEMBL361200 | 0.83 | LTB4R (0.39) | PKM | |
| SCHEMBL15110756 | 0.83 | LTB4R (0.39) | PKM | |
| SCHEMBL360807 | 0.83 | LTB4R (0.39) | PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8754085-B2 | Pyrido[2,3-b]pyrazine compounds useful as IP receptor agonist | NOVARTIS AG (CH) | 2014-06-17 | — | — | US | disclosed |