Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BPTF | Q12830 | 5/20 | 0.50 |
| ▸ | CETP | P11597 | 1/20 | 0.40 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.39 |
| ▸ | HTR2C | P28335 | 2/20 | 0.38 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | HTR3B | O95264 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | HTR7 | P34969 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | HTR3A | P46098 | 1/20 | 0.38 |
| ▸ | HTR6 | P50406 | 1/20 | 0.38 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21414340 | 0.89 | BPTF (0.54) | BPTFHTR2CHTR3EKDM4EUSP2 | |
| SCHEMBL21414326 | 0.83 | BPTF (0.57) | BPTFHTR2CHTR3EKDM4EUSP2 | |
| SCHEMBL15742052 | 0.76 | BPTF (0.47) | BPTFHRH4HTR2CCYP3A4PLD1 | |
| SCHEMBL22941955 | 0.73 | KCNH2 (0.61) | HTR2CKDM4EALDH1A1CYP3A4SLC6A4 | |
| SCHEMBL3640716 | 0.71 | HRH3 (0.52) | CETPHRH4HTR2CHTR3EKDM4E | |
| SCHEMBL7363690 | 0.71 | AOC3 (0.54) | HRH4HTR2CADRB1HTR6PLD1 | |
| SCHEMBL5330907 | 0.71 | CETP (0.49) | CETPHRH4HTR2CKDM4EALDH1A1 | |
| SCHEMBL4563936 | 0.71 | HTR2C (0.37) | BPTFCETPHRH4HTR2CKDM4E | |
| SCHEMBL12356537 | 0.71 | KCNH2 (0.59) | HTR2CKDM4EALDH1A1CYP3A4SLC6A4 | |
| SCHEMBL8326134 | 0.71 | BPTF (0.62) | BPTFHTR2CHTR3EKDM4EUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8530474-B2 | Substituted 6-(1-piperazinyl)-pyridazines as 5-HT6 receptor antagonists | JANSSEN PHARMACEUTICA NV (BE) | 2013-09-10 | — | — | US | disclosed |
| EP-2310374-B1 | SUBSTITUTED 6- (1-PIPERAZINYL) -PYRIDAZINES AS 5-HT6 RECEPTOR ANTAGONISTS | JANSSEN PHARMACEUTICA NV (BE) | 2012-10-31 | — | — | EP | disclosed |
| US-20110112107-A1 | SUBSTITUTED 6-(1-PIPERAZINYL)-PYRIDAZINES AS 5-HT6 RECEPTOR ANTAGONISTS | JANSSEN-CILAG S.A. (ES) | 2011-05-12 | — | — | US | disclosed |
| EP-2310374-A1 | SUBSTITUTED 6- (1-PIPERAZINYL) -PYRIDAZINES AS 5-HT6 RECEPTOR ANTAGONISTS | Janssen Pharmaceutica N.V. (BE) | 2011-04-20 | — | — | EP | disclosed |
| WO-2010000456-A1 | SUBSTITUTED 6- (1-PIPERAZINYL) -PYRIDAZINES AS 5-HT6 RECEPTOR ANTAGONISTS | JANSSEN PHARMACEUTICA NV (BE) | 2010-01-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110112107-A1 | SUBSTITUTED 6-(1-PIPERAZINYL)-PYRIDAZINES AS 5-HT6 RECEPTOR ANTAGONISTS | HTR6, HTR5A, HTR1A | BPTF 2547/4885CETP 4454/4885HRH4 60/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.