Known targets — ChEMBL curated mechanism
ABL1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB2AGTR1BCL2BCL2A1BCL2L1BCL2L10BCL2L2BCRBRAFCHRM1CHRNA10CHRNA9DRD1DRD2DRD3DRD4DRD5EGFRF2FLT1FLT4GCKGHSRGNRHRGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHTR1AHTR1BHTR1DHTR2AHTR2CHTR3AIDH2KDRKITMAOBMCL1MTTPPP4HBPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PIKFYVEROCK1ROCK2SLC18A2SLC6A2SLC6A3SLC6A4TACR1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8gyrAgyrBparCparEpol
The experimentally established mechanism targets of Metitepine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A known ✓ | P08908 | 2/20 | 0.68 |
| ▸ | HTR2A known ✓ | P28223 | 2/20 | 0.68 |
| ▸ | HTR2C known ✓ | P28335 | 7/20 | 0.58 |
| ▸ | DRD2 known ✓ | P14416 | 13/20 | 0.47 |
| ▸ | DRD4 known ✓ | P21917 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 4/20 | 0.68 |
| ▸ | HTR7 | P34969 | 4/20 | 0.68 |
| ▸ | TP53 | P04637 | 4/20 | 0.68 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.68 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.68 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.68 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.68 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.68 |
| ▸ | MEN1 | O00255 | 2/20 | 0.68 |
| ▸ | LMNA | P02545 | 2/20 | 0.68 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.68 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.68 |
| ▸ | THPO | P40225 | 2/20 | 0.68 |
| ▸ | GMNN | O75496 | 1/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Metitepine SCHEMBL31360614 | 0.82 | MAPT (1.00) | MAPTHTR7TP53CYP3A4SMN1; SMN2 | |
| Metitepine SCHEMBL466985 | 0.82 | MAPT (1.00) | MAPTHTR7TP53CYP3A4SMN1; SMN2 | |
| Metitepine SCHEMBL7517783 | 0.76 | HTR7 (1.00) | MAPTHTR7TP53CYP3A4SMN1; SMN2 | |
| Metitepine SCHEMBL113526 | 0.76 | HTR7 (1.00) | MAPTHTR7TP53CYP3A4SMN1; SMN2 | |
| Metitepine SCHEMBL29496251 | 0.76 | HTR7 (1.00) | MAPTHTR7TP53CYP3A4SMN1; SMN2 | |
| Metitepine SCHEMBL14359602 | 0.76 | HTR7 (1.00) | MAPTHTR7TP53CYP3A4SMN1; SMN2 | |
| Metitepine SCHEMBL8169076 | 0.73 | HTR7 (0.89) | MAPTHTR7TP53CYP3A4SMN1; SMN2 | |
| Metitepine SCHEMBL15475310 | 0.72 | MAPT (1.00) | MAPTHTR7TP53CYP3A4SMN1; SMN2 | |
| Metitepine SCHEMBL2048660 | 0.72 | MAPT (1.00) | MAPTHTR7TP53CYP3A4SMN1; SMN2 | |
| SCHEMBL11846588 | 0.69 | MAPT (0.75) | MAPTHTR7TP53CYP3A4SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2935567-A2 | DIFFERENTIATED CELL POPULATION OF ENDOTHELIAL CELLS DERIVED FROM HUMAN PLURIPOTENT STEM CELLS, COMPOSITION, SYSTEM, KIT AND USES THEREOF | CNC - Centro de Neurociências E Biologia Molecular - Universidade de Coimbra (PT) | 2015-10-28 | — | — | EP | disclosed |
| WO-2014097192-A2 | DIFFERENTIATED CELL POPULATION OF ENDOTHELIAL CELLS DERIVED FROM HUMAN PLURIPOTENT STEM CELLS, COMPOSITION, SYSTEM, KIT AND USES THEREOF | CNC - CENTRO DE NEUROCIÊNCIAS E BIOLOGIA MOLECULAR - UNIVERSIDADE DE COIMBRA (PT) | 2014-06-26 | — | — | WO | disclosed |