Sugi Predict

Sugi Predict / Compounds / SCHEMBL15828219

SCHEMBL15828219

SCHEMBL15828219

C[C@H](CCC(=O)O)NC(=O)NCCN

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ GABRP O00591 2/20 0.42
▸ GABRD O14764 2/20 0.42
▸ GABRA1 P14867 2/20 0.42
▸ GABRB1 P18505 2/20 0.42
▸ GABRG2 P18507 2/20 0.42
▸ GABRB3 P28472 2/20 0.42
▸ GABRA5 P31644 2/20 0.42
▸ GABRA3 P34903 2/20 0.42
▸ GABRA2 P47869 2/20 0.42
▸ GABRB2 P47870 2/20 0.42
▸ GABRA4 P48169 2/20 0.42
▸ GABRE P78334 2/20 0.42
▸ GABRA6 Q16445 2/20 0.42
▸ GABRG1 Q8N1C3 2/20 0.42
▸ GABRG3 Q99928 2/20 0.42
▸ GABRQ Q9UN88 2/20 0.42
▸ CYP1A2 P05177 1/20 0.42
▸ FOLH1 Q04609 6/20 0.41
▸ NAALAD2 Q9Y3Q0 2/20 0.41
▸ DPP4 P27487 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2742770 0.87 FOLH1 (0.48) FOLH1EPHX2PRMT1EPHX1SMN1; SMN2
SCHEMBL24253219 0.80 FOLH1 (0.42) GABRPGABRDGABRA1GABRB1GABRG2
SCHEMBL19788055 0.80 FOLH1 (0.42) FOLH1NAALAD2RIMKLAEPHX2PRMT1
SCHEMBL2742756 0.80 FOLH1 (0.42) FOLH1NAALAD2RIMKLAEPHX2PRMT1
SCHEMBL2742767 0.79 FOLH1 (0.67) FOLH1NAALAD2RIMKLA
SCHEMBL19788058 0.79 FOLH1 (0.67) FOLH1NAALAD2RIMKLA
SCHEMBL19265779 0.79 FOLH1 (0.61) GABRPGABRDGABRA1GABRB1GABRG2
SCHEMBL19360008 0.79 PRMT1 (0.49) FOLH1EPHX2PRMT1EPHX1SMN1; SMN2
SCHEMBL15275337 0.78 EPHX1 (0.49) FOLH1EPHX2PRMT1EPHX1SMN1; SMN2
SCHEMBL12118207 0.75 PRMT1 (0.45) FOLH1EPHX2PRMT1EPHX1SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20180125854-A1 THERAPEUTIC NANOPARTICLES COMPRISING A THERAPEUTIC AGENT AND METHODS OF MAKING AND USING THE SAME PFIZER INC. (US) 2018-05-10 — — US disclosed
US-9895378-B2 Therapeutic nanoparticles comprising a therapeutic agent and methods of making and using the same PFIZER INC. (US) 2018-02-20 — — US disclosed
US-20170151181-A1 METHODS OF TREATING CANCERS WITH THERAPEUTIC NANOPARTICLES PFIZER INC. (US) 2017-06-01 — — US disclosed
US-20170119672-A1 Therapeutic Nanoparticles Comprising A Therapeutic Agent And Methods Of Making And Using Same PFIZER INC. (US) 2017-05-04 — — US disclosed
US-20170042855-A1 NANOPARTICLES COMPRISING DOCETAXEL FOR TREATING CANCERS HAVING A K-RAS MUTATION BIND THERAPEUTICS, INC. 2017-02-16 — — US disclosed
US-20170042828-A1 THERAPEUTIC NANOPARTICLES COMPRISING A THERAPEUTIC AGENT AND METHODS OF MAKING AND USING SAME PFIZER INC. 2017-02-16 — — US disclosed
US-20150258102-A1 THERAPEUTIC NANOPARTICLES COMPRISING A THERAPEUTIC AGENT AND METHODS OF MAKING AND USING SAME PFIZER INC. 2015-09-17 — — US disclosed
US-20140249158-A1 Therapeutic Nanoparticles Comprising a Therapeutic Agent and Methods of Making and Using Same BIND THERAPEUTICS, INC. (US) 2014-09-04 — — US disclosed
US-20140248358-A1 Therapeutic Nanoparticles Comprising a Therapeutic Agent and Methods of Making and Using Same BIND THERAPEUTICS, INC. (US) 2014-09-04 — — US disclosed
US-20140178475-A1 Therapeutic Nanoparticles Comprising a Therapeutic Agent and Methods of Making and Using Same BIND THERAPEUTICS, INC. (US) 2014-06-26 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20140248358-A1 Therapeutic Nanoparticles Comprising a Therapeutic Agent and Methods of Making and Using Same CD44, NCL, TP53 GABRP 1727/4885GABRD 4452/4885GABRA1 3644/4885
US-20150258102-A1 THERAPEUTIC NANOPARTICLES COMPRISING A THERAPEUTIC AGENT AND METHODS OF MAKING AND USING SAME TP53, VHL, MTDH GABRP 498/4885GABRD 3289/4885GABRA1 1973/4885
US-20140178475-A1 Therapeutic Nanoparticles Comprising a Therapeutic Agent and Methods of Making and Using Same CD44, NCL, TP53 GABRP 1727/4885GABRD 4452/4885GABRA1 3644/4885
US-20170119672-A1 Therapeutic Nanoparticles Comprising A Therapeutic Agent And Methods Of Making And Using Same CD44, NCL, TP53 GABRP 1727/4885GABRD 4452/4885GABRA1 3644/4885
US-20140249158-A1 Therapeutic Nanoparticles Comprising a Therapeutic Agent and Methods of Making and Using Same CD44, NCL, TP53 GABRP 1727/4885GABRD 4452/4885GABRA1 3644/4885
US-20180125854-A1 THERAPEUTIC NANOPARTICLES COMPRISING A THERAPEUTIC AGENT AND METHODS OF MAKING AND USING THE SAME TP53, HNRNPH3, VHL GABRP 884/4885GABRD 4028/4885GABRA1 2758/4885
US-20170042828-A1 THERAPEUTIC NANOPARTICLES COMPRISING A THERAPEUTIC AGENT AND METHODS OF MAKING AND USING SAME CD44, NCL, TP53 GABRP 1727/4885GABRD 4452/4885GABRA1 3644/4885
US-20170151181-A1 METHODS OF TREATING CANCERS WITH THERAPEUTIC NANOPARTICLES KRAS, TP53, NRAS GABRP 4410/4885GABRD 4734/4885GABRA1 4680/4885
US-20170042855-A1 NANOPARTICLES COMPRISING DOCETAXEL FOR TREATING CANCERS HAVING A K-RAS MUTATION KRAS, NRAS, HRAS GABRP 4751/4885GABRD 4822/4885GABRA1 4819/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

Send feedback