Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FOLH1 | Q04609 | 12/20 | 0.67 |
| ▸ | NAALAD2 | Q9Y3Q0 | 5/20 | 0.67 |
| ▸ | RIMKLA | Q8IXN7 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19788058 | 1.00 | FOLH1 (0.67) | FOLH1NAALAD2RIMKLA | |
| SCHEMBL15896221 | 0.89 | FOLH1 (0.66) | FOLH1NAALAD2RIMKLA | |
| SCHEMBL19360000 | 0.89 | FOLH1 (0.74) | FOLH1NAALAD2RIMKLA | |
| SCHEMBL14720004 | 0.87 | FOLH1 (0.74) | FOLH1NAALAD2RIMKLA | |
| SCHEMBL14719987 | 0.87 | FOLH1 (0.74) | FOLH1NAALAD2RIMKLA | |
| SCHEMBL19788056 | 0.87 | FOLH1 (0.72) | FOLH1NAALAD2RIMKLA | |
| SCHEMBL21321739 | 0.87 | FOLH1 (0.72) | FOLH1NAALAD2RIMKLA | |
| SCHEMBL2742760 | 0.87 | FOLH1 (0.72) | FOLH1NAALAD2RIMKLA | |
| SCHEMBL14549933 | 0.84 | FOLH1 (0.69) | FOLH1NAALAD2RIMKLA | |
| SCHEMBL14330732 | 0.84 | FOLH1 (0.69) | FOLH1NAALAD2RIMKLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 39 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9877923-B2 | Process for preparing therapeutic nanoparticles | PFIZER INC. (US) | 2018-01-30 | — | — | US | disclosed |
| US-20170266187-A1 | Pemetrexed Polymeric Nanoparticles And Methods Of Making And Using Same | PFIZER INC. (US) | 2017-09-21 | — | — | US | disclosed |
| US-20170266293-A1 | METHODS OF TREATING CANCERS WITH THERAPEUTIC NANOPARTICLES | PFIZER INC. (US) | 2017-09-21 | — | — | US | disclosed |
| US-20170209374-A1 | METHODS OF CONTROLLING THE MORPHOLOGY OF POLYMERIC NANOPARTICLES | PFIZER (US) | 2017-07-27 | — | — | US | disclosed |
| US-9579386-B2 | Drug loaded polymeric nanoparticles and methods of making and using same | PFIZER INC. (US) | 2017-02-28 | — | — | US | disclosed |
| US-20160367481-A1 | CANCER CELL TARGETING USING NANOPARTICLES | PFIZER INC. | 2016-12-22 | — | — | US | disclosed |
| US-20160354320-A1 | DRUG LOADED POLYMERIC NANOPARTICLES AND METHODS OF MAKING AND USING SAME | PFIZER INC. | 2016-12-08 | — | — | US | disclosed |
| US-20160338959-A1 | DRUG LOADED POLYMERIC NANOPARTICLES AND METHODS OF MAKING AND USING SAME | PFIZER INC. | 2016-11-24 | — | — | US | disclosed |
| US-9393310-B2 | Drug loaded polymeric nanoparticles and methods of making and using same | BIND THERAPEUTICS, INC. (US) | 2016-07-19 | — | — | US | disclosed |
| US-9375481-B2 | Drug loaded polymeric nanoparticles and methods of making and using same | BIND THERAPEUTICS, INC. (US) | 2016-06-28 | — | — | US | disclosed |
| US-20130115192-A1 | Methods for the Preparation of Targeting Agent Functionalized Diblock Copolymers for Use in Fabrication of Therapeutic Targeted Nanoparticles | BIND BIOSCIENCES, INC (US) | 2013-05-09 | — | — | US | disclosed |
| US-8318208-B1 | Drug loaded polymeric nanoparticles and methods of making and using same | BIND BIOSCIENCES, INC. (US) | 2012-11-27 | — | — | US | disclosed |
| US-20120288541-A1 | Drug Loaded Polymeric Nanoparticles and Methods of Making and Using Same | PFIZER INC. | 2012-11-15 | — | — | US | disclosed |
| US-20120276162-A1 | Drug Loaded Polymeric Nanoparticles and Methods of Making and Using Same | PFIZER INC. | 2012-11-01 | — | — | US | disclosed |
| US-8293276-B2 | Drug loaded polymeric nanoparticles and methods of making and using same | BIND BIOSCIENCES, INC. (US) | 2012-10-23 | — | — | US | disclosed |
| US-8273363-B2 | Cancer cell targeting using nanoparticles | BIND BIOSCIENCES, INC. (US) | 2012-09-25 | — | — | US | disclosed |
| US-8236330-B2 | Cancer cell targeting using nanoparticles | BIND BIOSCIENCES, INC. (US) | 2012-08-07 | — | — | US | disclosed |
| US-20120004293-A1 | Cancer Cell Targeting Using Nanoparticles | PFIZER INC. | 2012-01-05 | — | — | US | disclosed |
| US-20110274759-A1 | Drug Loaded Polymeric Nanoparticles and Methods of Making and Using Same | PFIZER INC. | 2011-11-10 | — | — | US | disclosed |
| US-20110224288-A1 | Cancer Cell Targeting Using Nanoparticles | PFIZER INC. | 2011-09-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (12 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120276162-A1 | Drug Loaded Polymeric Nanoparticles and Methods of Making and Using Same | CD47, LPXN, CD44 | FOLH1 173/4885NAALAD2 2614/4885RIMKLA 1707/4885 |
| US-20160354320-A1 | DRUG LOADED POLYMERIC NANOPARTICLES AND METHODS OF MAKING AND USING SAME | CD47, LPXN, CD44 | FOLH1 173/4885NAALAD2 2614/4885RIMKLA 1707/4885 |
| US-20110274759-A1 | Drug Loaded Polymeric Nanoparticles and Methods of Making and Using Same | LDHA, LDHB, LPXN | FOLH1 177/4885NAALAD2 2442/4885RIMKLA 1489/4885 |
| US-20160338959-A1 | DRUG LOADED POLYMERIC NANOPARTICLES AND METHODS OF MAKING AND USING SAME | LDHA, LDHB, LPXN | FOLH1 177/4885NAALAD2 2442/4885RIMKLA 1489/4885 |
| US-20110224288-A1 | Cancer Cell Targeting Using Nanoparticles | CD47, EPCAM, CD44 | FOLH1 279/4885NAALAD2 1525/4885RIMKLA 3697/4885 |
| US-20130115192-A1 | Methods for the Preparation of Targeting Agent Functionalized Diblock Copolymers for Use in Fabrication of Therapeutic Targeted Nanoparticles | GNE, PAM, EPHA2 | FOLH1 727/4885NAALAD2 747/4885RIMKLA 519/4885 |
| US-20170266293-A1 | METHODS OF TREATING CANCERS WITH THERAPEUTIC NANOPARTICLES | CD47, NCL, NOP56 | FOLH1 154/4885NAALAD2 3432/4885RIMKLA 3409/4885 |
| US-20120288541-A1 | Drug Loaded Polymeric Nanoparticles and Methods of Making and Using Same | CD47, LPXN, CD44 | FOLH1 173/4885NAALAD2 2614/4885RIMKLA 1707/4885 |
| US-20170209374-A1 | METHODS OF CONTROLLING THE MORPHOLOGY OF POLYMERIC NANOPARTICLES | CLTB, NCL, CLTA | FOLH1 976/4885NAALAD2 3338/4885RIMKLA 1468/4885 |
| US-20170266187-A1 | Pemetrexed Polymeric Nanoparticles And Methods Of Making And Using Same | MTHFD1, TYMP, FPGS | FOLH1 51/4885NAALAD2 3323/4885RIMKLA 482/4885 |
| US-20120004293-A1 | Cancer Cell Targeting Using Nanoparticles | CD47, EPCAM, CD44 | FOLH1 279/4885NAALAD2 1525/4885RIMKLA 3697/4885 |
| US-20160367481-A1 | CANCER CELL TARGETING USING NANOPARTICLES | CD47, EPCAM, CD44 | FOLH1 279/4885NAALAD2 1525/4885RIMKLA 3697/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.