Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPIB | P23284 | 4/20 | 0.77 |
| ▸ | PPID | Q08752 | 2/20 | 0.47 |
| ▸ | PPIG | Q13427 | 2/20 | 0.47 |
| ▸ | PPIA | P62937 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | PYGL | P06737 | 1/20 | 0.39 |
| ▸ | DRD4 | P21917 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | THRA | P10827 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12643950 | 0.87 | PPIB (1.00) | PPIBPPIDPPIGPPIASMN1; SMN2 | |
| SCHEMBL15832161 | 0.76 | PPIB (0.79) | PPIBPPIDPPIGPPIAKMT2A | |
| SCHEMBL16270327 | 0.75 | PPIB (0.79) | PPIBPPIDPPIGKMT2AMEN1 | |
| SCHEMBL15832160 | 0.74 | PPIB (0.44) | PPIBPPIDPPIGKMT2AMEN1 | |
| SCHEMBL12643848 | 0.73 | PPIB (1.00) | PPIBPPIDPPIGPPIAKMT2A | |
| SCHEMBL15832143 | 0.72 | PPID (0.47) | PPIBPPIDPPIGPPIAEPHX2 | |
| SCHEMBL6961451 | 0.71 | PPIB (0.57) | PPIBPPIDPPIGPPIAKMT2A | |
| SCHEMBL12643766 | 0.71 | PPIB (0.71) | PPIBPPIDPPIGPPIAKMT2A | |
| SCHEMBL14667454 | 0.70 | PPIB (0.55) | PPIBKMT2ADRD4MEN1CYP2C19 | |
| SCHEMBL14575948 | 0.70 | PPIB (0.62) | PPIBPPIDPPIGPPIAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140179687-A1 | New Inhibitors of Cyclophilins and Uses Thereof | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) (FR) | 2014-06-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140179687-A1 | New Inhibitors of Cyclophilins and Uses Thereof | FKBP3, FKBP4, FKBP5 | PPIB 51/4885PPID 73/4885PPIG 28/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.