Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 2/20 | 0.48 |
| ▸ | GRM5 | P41594 | 1/20 | 0.48 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.45 |
| ▸ | TGM2 | P21980 | 1/20 | 0.44 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.44 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.44 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.43 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1583805 | 0.88 | NR1H2 (0.44) | HPGDSGRM5GRM1NR1H2P2RX7 | |
| SCHEMBL5891913 | 0.87 | P2RX7 (0.58) | TP53USP30MKNK1NR1H2P2RX7 | |
| SCHEMBL22650344 | 0.87 | NR1H2 (0.53) | USP30NR1H2P2RX7GPR119 | |
| SCHEMBL30998085 | 0.87 | NR1H2 (0.53) | USP30NR1H2P2RX7GPR119 | |
| SCHEMBL19690382 | 0.86 | USP30 (0.45) | USP30NR1H2P2RX7GPR119 | |
| SCHEMBL6982296 | 0.85 | LIPE (0.47) | USP30NR1H2P2RX7GPR119 | |
| SCHEMBL1583532 | 0.85 | P2RX7 (0.51) | GRM5GRM1NR1H2P2RX7ENPP2 | |
| SCHEMBL3068738 | 0.85 | GPR119 (0.53) | GRM5GRM1USP30NR1H2GPR119 | |
| SCHEMBL1583449 | 0.83 | GRM5 (0.46) | GRM5USP30NR1H2P2RX7GPR119 | |
| SCHEMBL30998103 | 0.83 | MAPT (0.55) | USP30NR1H2ENPP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011041713-A2 | PIPERAZINYL ANTIVIRAL AGENTS | GLAXOSMITHKLINE LLC (US) | 2011-04-07 | — | — | WO | disclosed |