Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPR | P35270 | 10/20 | 0.79 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.71 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.71 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.71 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.71 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.71 |
| ▸ | MAPT | P10636 | 1/20 | 0.71 |
| ▸ | IDO1 | P14902 | 1/20 | 0.71 |
| ▸ | HPGD | P15428 | 1/20 | 0.71 |
| ▸ | BLM | P54132 | 1/20 | 0.71 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.71 |
| ▸ | TRPV1 | Q8NER1 | 5/20 | 0.67 |
| ▸ | LMNA | P02545 | 1/20 | 0.62 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.62 |
| ▸ | MEN1 | O00255 | 1/20 | 0.62 |
| ▸ | HTR2C | P28335 | 1/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12720729 | 0.88 | SPR (1.00) | SPRKDM4EALDH1A1NPSR1CYP2D6 | |
| SCHEMBL14297204 | 0.88 | SPR (0.77) | SPRKDM4EALDH1A1CYP2D6CYP1A2 | |
| SCHEMBL12720728 | 0.87 | SPR (0.74) | SPRKDM4EALDH1A1NPSR1CYP2D6 | |
| SCHEMBL12720741 | 0.87 | SPR (0.75) | SPRKDM4EALDH1A1NPSR1CYP2D6 | |
| SCHEMBL12720806 | 0.87 | SPR (1.00) | SPRMAPTNOTUMTRPV1MEN1 | |
| SCHEMBL1131640 | 0.86 | SPR (0.76) | SPRKDM4EALDH1A1NPSR1CYP2D6 | |
| SCHEMBL14297219 | 0.86 | SPR (0.73) | SPRKDM4EALDH1A1NPSR1CYP2D6 | |
| SCHEMBL12720852 | 0.86 | SPR (0.73) | SPRKDM4EALDH1A1NPSR1CYP2D6 | |
| SCHEMBL4686124 | 0.85 | TRPV1 (0.84) | SPRKDM4EALDH1A1NPSR1CYP2D6 | |
| SCHEMBL12720829 | 0.85 | SPR (0.72) | SPRKDM4EALDH1A1CYP2D6CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130210826-A1 | METHODS FOR TREATING PAIN | THE GENERAL HOSPITAL CORPORATION (US) | 2013-08-15 | — | — | US | claimed |
| US-20110207753-A1 | METHODS FOR TREATING PAIN | THE GENERAL HOSPITAL CORPORATION (US) | 2011-08-25 | — | — | US | claimed |
| EP-1696877-A2 | METHODS FOR TREATING PAIN | THE GENERAL HOSPITAL CORPORATION (US) | 2006-09-06 | — | — | EP | claimed |
| US-20050197341-A1 | Methods for treating pain | GENERAL HOSPITAL CORPORATION, THE | 2005-09-08 | — | — | US | claimed |
| WO-2005048926-A2 | METHODS FOR TREATING PAIN | THE GENERAL HOSPITAL CORPORATION (US) | 2005-06-02 | — | — | WO | claimed |
| EP-1477165-A2 | Blocking induction of tetrahydrobiopterin to block induction of nitric oxide synthesis | Cornell Research Foundation, INC. (US) | 2004-11-17 | — | — | EP | claimed |
| WO-2019175332-A1 | BH4 PATHWAY INHIBITION AND USE THEREOF FOR TREATING T-CELL MEDIATED AUTOIMMUNE DISEASES OR HYPERSENSITIVITY | IMBA - INSTITUT FÜR MOLEKULARE BIOTECHNOLOGIE GMBH (AT) | 2019-09-19 | — | — | WO | disclosed |
| US-10059664-B2 | Sepiapterin reductase inhibitors for the treatment of pain | CHILDREN'S MEDICAL CENTER CORPORATION (US) | 2018-08-28 | — | — | US | disclosed |
| US-20160031812-A1 | SEPIAPTERIN REDUCTASE INHIBITORS FOR THE TREATMENT OF PAIN | SOLACE PHARMACEUTICALS UK LTD. (GB) | 2016-02-04 | — | — | US | disclosed |
| US-9169234-B2 | Sepiapterin reductase inhibitors for the treatment of pain | CHILDREN'S MEDICAL CENTER CORPORATION (US) | 2015-10-27 | — | — | US | disclosed |
| US-20130210826-A1 | METHODS FOR TREATING PAIN | THE GENERAL HOSPITAL CORPORATION (US) | 2013-08-15 | — | — | US | disclosed |
| US-20120322800-A1 | Sepiapterin Reductase Inhibitors For The Treatment of Pain | SOLACE PHARMACEUTICALS UK LTD. (GB) | 2012-12-20 | — | — | US | disclosed |
| EP-2488025-A1 | SEPIAPTERIN REDUCTASE INHIBITORS FOR THE TREATMENT OF PAIN | Children's Medical Center Corporation (US) | 2012-08-22 | — | — | EP | disclosed |
| US-20050197341-A1 | Methods for treating pain | GENERAL HOSPITAL CORPORATION, THE | 2005-09-08 | — | — | US | disclosed |
| WO-2005048926-A2 | METHODS FOR TREATING PAIN | THE GENERAL HOSPITAL CORPORATION (US) | 2005-06-02 | — | — | WO | disclosed |
| EP-1477165-A2 | Blocking induction of tetrahydrobiopterin to block induction of nitric oxide synthesis | Cornell Research Foundation, INC. (US) | 2004-11-17 | — | — | EP | disclosed |
| EP-1477165-A2 | Blocking induction of tetrahydrobiopterin to block induction of nitric oxide synthesis | Cornell Research Foundation, INC. (US) | 2004-11-17 | — | — | EP | disclosed |
| US-6153615-A | Blocking induction of tetrahydrobioterin to block induction of nitric oxide synthesis | CORNELL RESEARCH FOUNDATION, INC. (US) | 2000-11-28 | — | — | US | disclosed |
| US-5880124-A | Blocking induction of tetrahydrobiopterin to block induction of nitric oxide synthesis | CORNELL RESEARCH FOUNDATION, INC. (US) | 1999-03-09 | — | — | US | disclosed |
| US-5877176-A | Blocking induction of tetrahydrobiopterin to block induction of nitric oxide synthesis | CORNELL RESEARCH FOUNDATION, INC. (US) | 1999-03-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160031812-A1 | SEPIAPTERIN REDUCTASE INHIBITORS FOR THE TREATMENT OF PAIN | SPR, QDPR, SRR | SPR 1/4885KDM4E 3528/4885ALDH1A1 788/4885 |
| US-20130210826-A1 | METHODS FOR TREATING PAIN | SPR, QDPR, SHMT1 | SPR 1/4885KDM4E 1344/4885ALDH1A1 1061/4885 |
| US-20120322800-A1 | Sepiapterin Reductase Inhibitors For The Treatment of Pain | SPR, QDPR, SRR | SPR 1/4885KDM4E 3528/4885ALDH1A1 788/4885 |
| US-20110207753-A1 | METHODS FOR TREATING PAIN | SPR, QDPR, SHMT1 | SPR 1/4885KDM4E 2785/4885ALDH1A1 998/4885 |
| US-20050197341-A1 | Methods for treating pain | SPR, QDPR, SHMT1 | SPR 1/4885KDM4E 2785/4885ALDH1A1 998/4885 |
| US-10059664-B2 | Sepiapterin reductase inhibitors for the treatment of pain | SPR, QDPR, SRR | SPR 1/4885KDM4E 3528/4885ALDH1A1 788/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.