Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Salicylic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.67 |
| ▸ | HPGD | P15428 | 6/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.67 |
| ▸ | CA12 | O43570 | 1/20 | 0.67 |
| ▸ | CA1 | P00915 | 1/20 | 0.67 |
| ▸ | CA2 | P00918 | 1/20 | 0.67 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.67 |
| ▸ | CA4 | P22748 | 1/20 | 0.67 |
| ▸ | CA6 | P23280 | 1/20 | 0.67 |
| ▸ | CA7 | P43166 | 1/20 | 0.67 |
| ▸ | CA9 | Q16790 | 1/20 | 0.67 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.67 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.67 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.45 |
| ▸ | G6PD | P11413 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Salicylic Acid SCHEMBL5874177 | 1.00 | KDM4E (0.67) | KDM4EALDH1A1HPGDSMN1; SMN2CA12 | |
| Salicylic Acid SCHEMBL5313430 | 1.00 | KDM4E (0.67) | KDM4EALDH1A1HPGDSMN1; SMN2CA12 | |
| Salicylic Acid SCHEMBL19717848 | 1.00 | KDM4E (0.67) | KDM4EALDH1A1HPGDSMN1; SMN2CA12 | |
| Salicylic Acid SCHEMBL10788832 | 1.00 | KDM4E (0.67) | KDM4EALDH1A1HPGDSMN1; SMN2CA12 | |
| Salicylic Acid SCHEMBL1904685 | 1.00 | KDM4E (0.67) | KDM4EALDH1A1HPGDSMN1; SMN2CA12 | |
| Salicylic Acid SCHEMBL15717117 | 1.00 | KDM4E (0.67) | KDM4EALDH1A1HPGDSMN1; SMN2CA12 | |
| Salicylic Acid SCHEMBL2595372 | 0.98 | KDM4E (0.64) | KDM4EALDH1A1HPGDSMN1; SMN2CA12 | |
| Salicylic Acid SCHEMBL1131781 | 0.89 | KDM4E (0.53) | KDM4EALDH1A1HPGDSMN1; SMN2CA12 | |
| Salicylic Acid SCHEMBL6653091 | 0.89 | KDM4E (0.53) | KDM4EALDH1A1HPGDSMN1; SMN2CA12 | |
| Phthalic Acid SCHEMBL5875171 | 0.88 | ALDH1A1 (0.61) | KDM4EALDH1A1HPGDSMN1; SMN2CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 10592 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2026099270-A1 | BIODEGRADABLE UV ABSORBERS AND USES THEREOF II | BASF SE (DE) | 2026-05-15 | — | — | WO | claimed |
| US-20260130837-A1 | SPF BOOSTER AND SUNCARE FORMULATIONS INCLUDING SAME | DOW SILICONES CORP (US) | 2026-05-14 | — | — | US | claimed |
| EP-3600224-B1 | SKIN CARE COMPOSITIONS COMPRISING A TERPOLYMER, PROCESS FOR PREPARING THE SAME AND METHOD OF USE THEREOF | ISP INVESTMENTS LLC (US) | 2026-05-06 | — | — | EP | claimed |
| WO-2026089856-A1 | METHOD OF PREPARING AND USING A SKIN CARE FORMULATION | DOW SILICONES CORPORATION (US) | 2026-04-30 | — | — | WO | claimed |
| WO-2026089857-A1 | METHOD OF PREPARING AND USING A SKIN CARE COMPOSITION | DOW SILICONES CORPORATION (US) | 2026-04-30 | — | — | WO | claimed |
| US-20260108436-A1 | SUNSCREEN COMPOSITION WITH SPF BOOSTERS | SAES GETTERS S.P.A. (IT) | 2026-04-23 | — | — | US | claimed |
| US-20260076889-A1 | POLYESTER FILM-FORMING POLYMERS FOR ALCOHOLBASED SUNSCREEN FORMULATIONS | NOURYON CHEMICALS INTERNATIONAL B.V. (NL) | 2026-03-19 | — | — | US | claimed |
| EP-4648735-B1 | SUNSCREEN COMPOSITION WITH SPF BOOSTERS | GETTERS SPA (IT) | 2026-03-11 | — | — | EP | claimed |
| EP-4061326-B1 | PERSONAL CARE COMPOSITION COMPRISING A MULTISTAGE POLYMER | DOW GLOBAL TECHNOLOGIES LLC (US) | 2026-02-25 | — | — | EP | claimed |
| US-12544332-B2 | Lipid vesicle compositions with penetration enhancing agents | DDS RESEARCH INC. (CA) | 2026-02-10 | — | — | US | claimed |
| EP-0073758-B1 | TREATMENT OF INFLAMMATORY VIRAL INFECTIONS, ACNE, DERMATITIS AND ARTHRITIS CONDITIONS | McHUGH, John Edward (US) | 1985-07-17 | — | — | EP | claimed |
| US-4511563-A | NONIONIC SURFACTANT, GLYCERIN | BASF WYANDOTTE CORPORATION (US) | 1985-04-16 | — | — | US | claimed |
| EP-0126684-A2 | Drug delivery system utilizing thermosetting gels | MERCK & CO. INC. (US) | 1984-11-28 | — | — | EP | claimed |
| US-4476115-A | Analgesic composition and method of treating subdermal pain | REED RAYMOND E | 1984-10-09 | — | — | US | claimed |
| US-4474753-A | POLYETHERAMINE | MERCK & CO., INC. (US) | 1984-10-02 | — | — | US | claimed |
| EP-0073758-A4 | TREATMENT OF INFLAMMATORY VIRAL INFECTIONS, ACNE, DERMATITIS AND ARTHRITIS CONDITIONS. | MCHUGH JOHN EDWARD | 1983-07-04 | — | — | EP | claimed |
| EP-0073758-A1 | TREATMENT OF INFLAMMATORY VIRAL INFECTIONS, ACNE, DERMATITIS AND ARTHRITIS CONDITIONS. | MCHUGH JOHN EDWARD | 1983-03-16 | — | — | EP | claimed |
| US-4353896-A | CORTICOSTEROID AND COUNTERIRRITANT IN PENETRATING SOLVENT | LEVY MICHAEL A | 1982-10-12 | — | — | US | claimed |
| WO-1982003010-A1 | TREATMENT OF INFLAMMATORY VIRAL INFECTIONS,ACNE,DERMATITIS AND ARTHRITIS CONDITIONS | MCHUGH JOHN EDWARD | 1982-09-16 | — | — | WO | claimed |
| US-4217344-A | Compositions containing aqueous dispersions of lipid spheres | L'OREAL (FR) | 1980-08-12 | — | — | US | claimed |