Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Salicylic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.67 |
| ▸ | HPGD | P15428 | 6/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.67 |
| ▸ | CA12 | O43570 | 1/20 | 0.67 |
| ▸ | CA1 | P00915 | 1/20 | 0.67 |
| ▸ | CA2 | P00918 | 1/20 | 0.67 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.67 |
| ▸ | CA4 | P22748 | 1/20 | 0.67 |
| ▸ | CA6 | P23280 | 1/20 | 0.67 |
| ▸ | CA7 | P43166 | 1/20 | 0.67 |
| ▸ | CA9 | Q16790 | 1/20 | 0.67 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.67 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.67 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.45 |
| ▸ | G6PD | P11413 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Salicylic Acid SCHEMBL15847 | 1.00 | KDM4E (0.67) | KDM4EALDH1A1HPGDSMN1; SMN2CA12 | |
| Salicylic Acid SCHEMBL5874177 | 1.00 | KDM4E (0.67) | KDM4EALDH1A1HPGDSMN1; SMN2CA12 | |
| Salicylic Acid SCHEMBL19717848 | 1.00 | KDM4E (0.67) | KDM4EALDH1A1HPGDSMN1; SMN2CA12 | |
| Salicylic Acid SCHEMBL10788832 | 1.00 | KDM4E (0.67) | KDM4EALDH1A1HPGDSMN1; SMN2CA12 | |
| Salicylic Acid SCHEMBL1904685 | 1.00 | KDM4E (0.67) | KDM4EALDH1A1HPGDSMN1; SMN2CA12 | |
| Salicylic Acid SCHEMBL15717117 | 1.00 | KDM4E (0.67) | KDM4EALDH1A1HPGDSMN1; SMN2CA12 | |
| Salicylic Acid SCHEMBL2595372 | 0.98 | KDM4E (0.64) | KDM4EALDH1A1HPGDSMN1; SMN2CA12 | |
| Salicylic Acid SCHEMBL1131781 | 0.89 | KDM4E (0.53) | KDM4EALDH1A1HPGDSMN1; SMN2CA12 | |
| Salicylic Acid SCHEMBL6653091 | 0.89 | KDM4E (0.53) | KDM4EALDH1A1HPGDSMN1; SMN2CA12 | |
| Phthalic Acid SCHEMBL5875171 | 0.88 | ALDH1A1 (0.61) | KDM4EALDH1A1HPGDSMN1; SMN2CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1155677-B1 | Compositions for inhibiting free radical polymerization in skin and hair | FAN TECH LTD (US) | 2007-06-13 | — | — | EP | disclosed |
| US-20030114532-A1 | Methods and compositions for inhibiting free radical polymerization in skin and hair | FAN TECH, LTD. | 2003-06-19 | — | — | US | disclosed |
| CN-1100523-C | Cosmetic product to prevent and correct skin damage | UNILEVER PLC (NL) | 2003-02-05 | — | — | CN | disclosed |
| US-20020094342-A1 | Methods and compositions for inhibiting free radical polymerization in skin and hair | FAN TECH, LTD. | 2002-07-18 | — | — | US | disclosed |
| EP-1155677-A2 | Methods and compositions for inhibiting free radical polymerization in skin and hair | Fan Tech Ltd. (US) | 2001-11-21 | — | — | EP | disclosed |
| CN-1191478-A | Cosmetic product to prevent and correct skin damage | UNILEVER PLC (NL) | 1998-08-26 | — | — | CN | disclosed |
| WO-1994020066-A1 | SUNSCREEN COMPOSITION | UNILEVER PLC (GB) | 1994-09-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020094342-A1 | Methods and compositions for inhibiting free radical polymerization in skin and hair | TST, BHMT2, TXN2 | KDM4E 1864/4885ALDH1A1 782/4885HPGD 351/4885 |
| US-20030114532-A1 | Methods and compositions for inhibiting free radical polymerization in skin and hair | TST, BHMT2, TXN2 | KDM4E 1864/4885ALDH1A1 782/4885HPGD 351/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.