Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Salicylic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.64 |
| ▸ | HPGD | P15428 | 6/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.64 |
| ▸ | CA12 | O43570 | 1/20 | 0.64 |
| ▸ | CA1 | P00915 | 1/20 | 0.64 |
| ▸ | CA2 | P00918 | 1/20 | 0.64 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.64 |
| ▸ | CA4 | P22748 | 1/20 | 0.64 |
| ▸ | CA6 | P23280 | 1/20 | 0.64 |
| ▸ | CA7 | P43166 | 1/20 | 0.64 |
| ▸ | CA9 | Q16790 | 1/20 | 0.64 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.64 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.64 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.44 |
| ▸ | G6PD | P11413 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Salicylic Acid SCHEMBL19717848 | 0.98 | KDM4E (0.67) | KDM4EALDH1A1HPGDSMN1; SMN2CA12 | |
| Salicylic Acid SCHEMBL5313430 | 0.98 | KDM4E (0.67) | KDM4EALDH1A1HPGDSMN1; SMN2CA12 | |
| Salicylic Acid SCHEMBL15717117 | 0.98 | KDM4E (0.67) | KDM4EALDH1A1HPGDSMN1; SMN2CA12 | |
| Salicylic Acid SCHEMBL10788832 | 0.98 | KDM4E (0.67) | KDM4EALDH1A1HPGDSMN1; SMN2CA12 | |
| Salicylic Acid SCHEMBL1904685 | 0.98 | KDM4E (0.67) | KDM4EALDH1A1HPGDSMN1; SMN2CA12 | |
| Salicylic Acid SCHEMBL5874177 | 0.98 | KDM4E (0.67) | KDM4EALDH1A1HPGDSMN1; SMN2CA12 | |
| Salicylic Acid SCHEMBL15847 | 0.98 | KDM4E (0.67) | KDM4EALDH1A1HPGDSMN1; SMN2CA12 | |
| Salicylic Acid SCHEMBL1131781 | 0.88 | KDM4E (0.53) | KDM4EALDH1A1HPGDSMN1; SMN2CA12 | |
| Salicylic Acid SCHEMBL6653091 | 0.88 | KDM4E (0.53) | KDM4EALDH1A1HPGDSMN1; SMN2CA12 | |
| Phthalic Acid SCHEMBL5875171 | 0.87 | ALDH1A1 (0.61) | KDM4EALDH1A1HPGDSMN1; SMN2CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240173451-A1 | FRAGRANCE COMPOSITIONS, METHODS OF MANUFACTURE THEREOF AND ARTICLES COMPRISING THE SAME | Exuud, Inc. | 2024-05-30 | — | — | US | claimed |
| EP-4294465-A1 | FRAGRANCE COMPOSITIONS, METHODS OF MANUFACTURE THEREOF AND ARTICLES COMPRISING THE SAME | Neerja Ventures, LLC (US) | 2023-12-27 | — | — | EP | claimed |
| US-9549886-B2 | Personal care formulations containing alkyl ketal esters and methods of manufacture | GFBIOCHEMICALS LIMITED (MT) | 2017-01-24 | — | — | US | claimed |
| US-20150064124-A1 | PERSONAL CARE FORMULATIONS CONTAINING ALKYL KETAL ESTERS AND METHODS OF MANUFACTURE | SEGETIS, INC. (US) | 2015-03-05 | — | — | US | claimed |
| EP-2568955-A2 | PERSONAL CARE FORMULATIONS CONTAINING ALKYL KETAL ESTERS AND METHODS OF MANUFACTURE | Segetis, Inc. (US) | 2013-03-20 | — | — | EP | claimed |
| CN-102883705-A | Personal care formulations containing alkyl ketal esters and methods of manufacture | SEGETIS INC | 2013-01-16 | — | — | CN | claimed |
| US-20110300083-A1 | PERSONAL CARE FORMULATIONS CONTAINING ALKYL KETAL ESTERS AND METHODS OF MANUFACTURE | SEGETIS, INC. (US) | 2011-12-08 | — | — | US | claimed |
| WO-2011143254-A2 | PERSONAL CARE FORMULATIONS CONTAINING ALKYL KETAL ESTERS AND METHODS OF MANUFACTURE | SEGETIS, INC. (US) | 2011-11-17 | — | — | WO | claimed |
| US-20240173451-A1 | FRAGRANCE COMPOSITIONS, METHODS OF MANUFACTURE THEREOF AND ARTICLES COMPRISING THE SAME | Exuud, Inc. | 2024-05-30 | — | — | US | disclosed |
| US-20230087601-A1 | COSMETIC COMPOSITIONS CONTAINING LOW MOLECULAR WEIGHT AMORPHOUS GRADE POLYLACTIC ACID RESIN | NATUREWORKS LLC | 2023-03-23 | — | — | US | disclosed |
| EP-4106881-A1 | COSMETIC COMPOSITIONS CONTAINING LOW MOLECULAR WEIGHT AMORPHOUS GRADE POLYLACTIC ACID RESIN | NatureWorks LLC (US) | 2022-12-28 | — | — | EP | disclosed |
| EP-2925738-B1 | CARBOXY ESTER KETALS, METHODS OF MANUFACTURE, AND USES THEREOF | GFBIOCHEMICALS LTD (MT) | 2018-01-10 | — | — | EP | disclosed |
| US-9549886-B2 | Personal care formulations containing alkyl ketal esters and methods of manufacture | GFBIOCHEMICALS LIMITED (MT) | 2017-01-24 | — | — | US | disclosed |
| US-9458414-B2 | Cleaning, surfactant, and personal care compositions | GFBIOCHEMICALS LIMITED (MT) | 2016-10-04 | — | — | US | disclosed |
| US-20140147395-A1 | CARBOXY ESTER KETALS, METHODS OF MANUFACTURE, AND USES THEREOF | SEGETIS, INC. (US) | 2014-05-29 | — | — | US | disclosed |
| WO-2014047428-A1 | CLEANING, SURFACTANT, AND PERSONAL CARE COMPOSITIONS | SEGETIS, INC. (US) | 2014-03-27 | — | — | WO | disclosed |
| EP-2568955-A2 | PERSONAL CARE FORMULATIONS CONTAINING ALKYL KETAL ESTERS AND METHODS OF MANUFACTURE | Segetis, Inc. (US) | 2013-03-20 | — | — | EP | disclosed |
| CN-102883705-A | Personal care formulations containing alkyl ketal esters and methods of manufacture | SEGETIS INC | 2013-01-16 | — | — | CN | disclosed |
| US-20110300083-A1 | PERSONAL CARE FORMULATIONS CONTAINING ALKYL KETAL ESTERS AND METHODS OF MANUFACTURE | SEGETIS, INC. (US) | 2011-12-08 | — | — | US | disclosed |
| WO-2011143254-A2 | PERSONAL CARE FORMULATIONS CONTAINING ALKYL KETAL ESTERS AND METHODS OF MANUFACTURE | SEGETIS, INC. (US) | 2011-11-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230087601-A1 | COSMETIC COMPOSITIONS CONTAINING LOW MOLECULAR WEIGHT AMORPHOUS GRADE POLYLACTIC ACID RESIN | CUTA, RARA, RARG | KDM4E 1542/4885ALDH1A1 2236/4885HPGD 3942/4885 |
| US-20110300083-A1 | PERSONAL CARE FORMULATIONS CONTAINING ALKYL KETAL ESTERS AND METHODS OF MANUFACTURE | KAT7, CUTA, KAT6B | KDM4E 67/4885ALDH1A1 1254/4885HPGD 2282/4885 |
| US-20150064124-A1 | PERSONAL CARE FORMULATIONS CONTAINING ALKYL KETAL ESTERS AND METHODS OF MANUFACTURE | KAT7, CUTA, KAT6B | KDM4E 67/4885ALDH1A1 1254/4885HPGD 2282/4885 |
| US-20140147395-A1 | CARBOXY ESTER KETALS, METHODS OF MANUFACTURE, AND USES THEREOF | C9, C5, C1S | KDM4E 65/4885ALDH1A1 769/4885HPGD 3498/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.