SCHEMBL15848468

SCHEMBL15848468

C=CCC[SiH2]OCc1ccccc1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 2/20 0.45
IDO1 P14902 1/20 0.38
ALOX15 P16050 1/20 0.36
AGXT P21549 1/20 0.36
APOBEC3G Q9HC16 1/20 0.34
BCHE P06276 3/20 0.33
CA1 P00915 3/20 0.33
CA2 P00918 3/20 0.33
CA9 Q16790 3/20 0.33
CA7 P43166 1/20 0.33
HCAR2 Q8TDS4 1/20 0.33
ALDH1A1 P00352 3/20 0.32
LMNA P02545 1/20 0.32
CYP1A2 P05177 1/20 0.32
PTGS1 P23219 1/20 0.32
SLC6A2 P23975 1/20 0.32
CYP2C19 P33261 1/20 0.32
PTGS2 P35354 1/20 0.32
SLC6A3 Q01959 1/20 0.32
HIF1A Q16665 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL675837 0.81 IDO1 (0.45) TSHRIDO1ALOX15AGXTAPOBEC3G
SCHEMBL3482051 0.75 TSHR (0.50) TSHRIDO1AGXTALDH1A1MAPK1
SCHEMBL5704258 0.73 TSHR (0.48) TSHRIDO1AGXTCA1CA2
SCHEMBL15848354 0.73 ALDH1A1 (0.46) TSHRALDH1A1HDAC6MAPK1L3MBTL1
SCHEMBL676431 0.72 TSHR (0.46) TSHRIDO1ALOX15AGXTCA1
SCHEMBL15327779 0.72 TSHR (0.46) TSHRIDO1AGXTCA1CA2
SCHEMBL705851 0.72 TSHR (0.46) TSHRIDO1AGXTALDH1A1MAPK1
SCHEMBL1867995 0.71 TSHR (0.56) TSHRIDO1ALOX15AGXTCA1
SCHEMBL7054298 0.70 CETP (0.45) TSHRALDH1A1MAPK1L3MBTL1
SCHEMBL5682848 0.70 TSHR (0.45) TSHRIDO1AGXTALDH1A1CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20150344735-A1 Curable Silicone Composition, Cured Product Thereof, And Optical Semiconductor Device DOW CORNING TORAY CO., LTD. (JP) 2015-12-03 US disclosed
WO-2014104388-A2 CURABLE SILICONE COMPOSITION, CURED PRODUCT THEREOF, AND OPTICAL SEMICONDUCTOR DEVICE DOW CORNING TORAY CO., LTD. (JP) 2014-07-03 WO disclosed