SCHEMBL5704258

SCHEMBL5704258

NCCC[SiH2]OCc1ccccc1

nearest known ligand 0.48

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
TSHR P16473 1/20 0.48
MAOA P21397 2/20 0.47
IDO1 P14902 1/20 0.45
AGXT P21549 1/20 0.43
HTR2A P28223 2/20 0.41
LOXL2 Q9Y4K0 2/20 0.41
SMN1; SMN2 Q16637 2/20 0.41
CYP2A6 P11509 1/20 0.41
TAAR1 Q96RJ0 1/20 0.41
MAOB P27338 2/20 0.39
CA1 P00915 1/20 0.38
CA2 P00918 1/20 0.38
CA9 Q16790 1/20 0.38
LTA4H P09960 1/20 0.38
GAA P10253 1/20 0.37
MAPT P10636 1/20 0.37
RAB9A P51151 1/20 0.37
L3MBTL1 Q9Y468 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15327779 0.82 TSHR (0.46) TSHRIDO1AGXTCA1CA2
SCHEMBL705851 0.82 TSHR (0.46) TSHRIDO1AGXTSMN1; SMN2L3MBTL1
SCHEMBL7054298 0.81 CETP (0.45) TSHRSMN1; SMN2L3MBTL1
SCHEMBL9716523 0.81 MAOA (0.53) MAOAIDO1HTR2ALOXL2SMN1; SMN2
SCHEMBL8804698 0.78 IDO1 (0.39) TSHRMAOAIDO1AGXTHTR2A
SCHEMBL6661880 0.78 TSHR (0.42) TSHRMAOAIDO1AGXTSMN1; SMN2
SCHEMBL3482051 0.78 TSHR (0.50) TSHRIDO1AGXTMAOBLTA4H
SCHEMBL15848468 0.73 TSHR (0.45) TSHRIDO1AGXTCA1CA2
SCHEMBL5682848 0.73 TSHR (0.45) TSHRIDO1AGXTSMN1; SMN2MAOB
SCHEMBL10612629 0.73 HTR2A (0.52) TSHRMAOAHTR2ATAAR1CA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1339727-B1 PROCESS FOR PREPARING PRIMARY AMINOORGANOSILANES GEN ELECTRIC (US) 2006-09-13 EP disclosed
EP-1339727-A1 PROCESS FOR PREPARING PRIMARY AMINOORGANOSILANES Crompton Corporation (US) 2003-09-03 EP disclosed
WO-2002046202-A1 PROCESS FOR PREPARING PRIMARY AMINOORGANOSILANES CROMPTON CORPORATION (US) 2002-06-13 WO disclosed
US-6242627-B1 BY DIRECT CATALYZED REACTION OF CYANOORGANOSILANE WITH HYDROGEN REDUCING SPONTANEOUS COMBUSTION HAZARD IN OXYGEN-CONTAINING ENVIRONMENT; ALKALI METAL ALKOXIDE INHIBITS OR SUPPRESS FORMATION OF SECONDARY AMINOORGANOSILANES CROMPTON COMPANY 2001-06-05 US disclosed
EP-0527007-B1 Process for preparation of primary aminoorganosilanes DOW CORNING (US) 1996-10-23 EP disclosed
EP-0527007-A1 Process for preparation of primary aminoorganosilanes DOW CORNING CORPORATION (US) 1993-02-10 EP disclosed
US-5117024-A Hydrogenation with hydrogen gas of cyanoorganosilane in the presence of a supported cobalt catalyst DOW CORNING CORPORATION (US) 1992-05-26 US disclosed