Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.80 |
| ▸ | NAMPT | P43490 | 13/20 | 0.74 |
| ▸ | LMNA | P02545 | 2/20 | 0.72 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30167720 | 1.00 | ALDH1A1 (0.80) | ALDH1A1NAMPTLMNAMAPK1 | |
| SCHEMBL19380062 | 0.89 | GAA (0.72) | ALDH1A1NAMPTLMNAMAPK1 | |
| SCHEMBL27312618 | 0.86 | ALDH1A1 (0.88) | ALDH1A1NAMPTLMNA | |
| SCHEMBL161512 | 0.85 | NAMPT (1.00) | ALDH1A1NAMPTLMNAMAPK1 | |
| SCHEMBL15953779 | 0.84 | LMNA (1.00) | ALDH1A1NAMPTLMNAMAPK1 | |
| SCHEMBL168368 | 0.83 | NAMPT (1.00) | NAMPT | |
| SCHEMBL19380186 | 0.81 | TP53 (0.68) | ALDH1A1LMNA | |
| SCHEMBL28806017 | 0.80 | ALDH1A1 (0.53) | ALDH1A1NAMPTLMNAMAPK1 | |
| SCHEMBL4467225 | 0.80 | CA2 (0.77) | NAMPT | |
| SCHEMBL933885 | 0.80 | TSHR (0.67) | ALDH1A1NAMPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 39 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230346753-A1 | NOVEL COMPOUNDS AND COMPOSITIONS FOR THE INHIBITION OF NAMPT | VALO HEALTH, INC. | 2023-11-02 | — | — | US | claimed |
| US-20200247795-A1 | NOVEL COMPOUND FOR INHIBITING NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE AND COMPOSITION CONTAINING SAME | CHECKMATE THERAPEUTICS INC. (KR) | 2020-08-06 | — | — | US | claimed |
| EP-3431472-A2 | NOVEL COMPOUND FOR INHIBITING NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE AND COMPOSITION CONTAINING SAME | Industry-Academic Cooperation Foundation Yonsei University (KR) | 2019-01-23 | — | — | EP | claimed |
| CN-108779104-A | Noval chemical compound for inhibiting Nampt and the composition comprising it | 延世大学校产学协力团 | 2018-11-09 | — | — | CN | claimed |
| US-20170368039-A1 | NOVEL COMPOUNDS AND COMPOSITIONS FOR THE INHIBITION OF NAMPT | FORMA TM, LLC (US) | 2017-12-28 | — | — | US | claimed |
| CN-103384668-B | compounds and compositions for inhibition of NAMPT | 福马TM有限责任公司 | 2017-05-31 | — | — | CN | claimed |
| US-20140294805-A1 | NOVEL COMPOUNDS AND COMPOSITIONS FOR THE INHIBITION OF NAMPT | VALO EARLY DISCOVERY, INC. | 2014-10-02 | — | — | US | claimed |
| US-12336981-B2 | Compounds and compositions for the inhibition of NAMPT | VALO HEALTH, INC. (US) | 2025-06-24 | — | — | US | disclosed |
| US-20230346753-A1 | NOVEL COMPOUNDS AND COMPOSITIONS FOR THE INHIBITION OF NAMPT | VALO HEALTH, INC. | 2023-11-02 | — | — | US | disclosed |
| US-11795163-B2 | Compound for inhibiting nicotinamide phosphoribosyltransferase and composition containing same | CHECKMATE THERAPEUTICS INC. | 2023-10-24 | — | — | US | disclosed |
| US-11795163-B2 | Compound for inhibiting nicotinamide phosphoribosyltransferase and composition containing same | CHECKMATE THERAPEUTICS INC. | 2023-10-24 | — | — | US | disclosed |
| US-11795163-B2 | Compound for inhibiting nicotinamide phosphoribosyltransferase and composition containing same | CHECKMATE THERAPEUTICS INC. | 2023-10-24 | — | — | US | disclosed |
| EP-3431472-B1 | NOVEL COMPOUND FOR INHIBITING NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE AND COMPOSITION CONTAINING SAME | CHECKMATE THERAPEUTICS INC (KR) | 2023-05-03 | — | — | EP | disclosed |
| EP-3431472-A2 | NOVEL COMPOUND FOR INHIBITING NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE AND COMPOSITION CONTAINING SAME | Industry-Academic Cooperation Foundation Yonsei University (KR) | 2019-01-23 | — | — | EP | disclosed |
| CN-108779104-A | Noval chemical compound for inhibiting Nampt and the composition comprising it | 延世大学校产学协力团 | 2018-11-09 | — | — | CN | disclosed |
| WO-2017160116-A9 | NOVEL COMPOUND FOR INHIBITING NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE AND COMPOSITION CONTAINING SAME | 연세대학교 산학협력단 | 2017-11-30 | — | — | WO | disclosed |
| WO-2017160116-A2 | NOVEL COMPOUND FOR INHIBITING NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE AND COMPOSITION CONTAINING SAME | 연세대학교 산학협력단 | 2017-09-21 | — | — | WO | disclosed |
| US-20140294805-A1 | NOVEL COMPOUNDS AND COMPOSITIONS FOR THE INHIBITION OF NAMPT | VALO EARLY DISCOVERY, INC. | 2014-10-02 | — | — | US | disclosed |
| EP-2611804-A1 | NOVEL COMPOUNDS AND COMPOSITIONS FOR THE INHIBITION OF NAMPT | Forma TM, LLC. (US) | 2013-07-10 | — | — | EP | disclosed |
| WO-2012031197-A1 | NOVEL COMPOUNDS AND COMPOSITIONS FOR THE INHIBITION OF NAMPT | FORMA THERAPEUTICS, INC. (US) | 2012-03-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200247795-A1 | NOVEL COMPOUND FOR INHIBITING NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE AND COMPOSITION CONTAINING SAME | NAMPT, NAPRT, NNMT | ALDH1A1 2533/4885NAMPT 1/4885LMNA 3629/4885 |
| US-12336981-B2 | Compounds and compositions for the inhibition of NAMPT | NAMPT, NNMT, NNT | ALDH1A1 984/4885NAMPT 1/4885LMNA 860/4885 |
| US-20170368039-A1 | NOVEL COMPOUNDS AND COMPOSITIONS FOR THE INHIBITION OF NAMPT | NAMPT, NNMT, NQO1 | ALDH1A1 1273/4885NAMPT 1/4885LMNA 1579/4885 |
| US-20140294805-A1 | NOVEL COMPOUNDS AND COMPOSITIONS FOR THE INHIBITION OF NAMPT | NAMPT, NNMT, NQO1 | ALDH1A1 1273/4885NAMPT 1/4885LMNA 1579/4885 |
| US-11795163-B2 | Compound for inhibiting nicotinamide phosphoribosyltransferase and composition containing same | NAMPT, NAPRT, NNT | ALDH1A1 1903/4885NAMPT 1/4885LMNA 3084/4885 |
| US-20230346753-A1 | NOVEL COMPOUNDS AND COMPOSITIONS FOR THE INHIBITION OF NAMPT | NAMPT, NNMT, NQO1 | ALDH1A1 1273/4885NAMPT 1/4885LMNA 1579/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.