Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | KCNK3 | O14649 | 2/20 | 0.46 |
| ▸ | RAD52 | P43351 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | BCHE | P06276 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12046633 | 0.92 | ACHE (0.44) | KDM4EKMT2AALDH1A1KCNK3RAD52 | |
| SCHEMBL12046659 | 0.83 | KDM4E (0.50) | KDM4EKMT2AALDH1A1LMNAMEN1 | |
| SCHEMBL12874910 | 0.83 | ALDH1A1 (0.34) | KDM4EKMT2AALDH1A1KCNK3LMNA | |
| SCHEMBL20925016 | 0.77 | ALDH1A1 (0.50) | KDM4EKMT2AALDH1A1LMNAMEN1 | |
| SCHEMBL14558121 | 0.74 | MAPT (0.46) | KDM4EKMT2AALDH1A1LMNAGAA | |
| SCHEMBL16334544 | 0.71 | GAA (0.39) | KDM4EKMT2AALDH1A1LMNAMEN1 | |
| SCHEMBL16377774 | 0.71 | GAA (0.39) | KDM4EKMT2AALDH1A1LMNAMEN1 | |
| SCHEMBL29538912 | 0.71 | GAA (0.39) | KDM4EKMT2AALDH1A1LMNAMEN1 | |
| SCHEMBL9466478 | 0.70 | KDM4E (0.56) | KDM4EKMT2AALDH1A1KCNK3LMNA | |
| SCHEMBL21538783 | 0.70 | KDM4E (0.56) | KDM4EKMT2AALDH1A1KCNK3LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2459551-B1 | DIHYDROBENZOINDAZOLES | MERCK SHARP & DOHME (NL) | 2014-07-02 | — | — | EP | disclosed |