Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.65 |
| ▸ | GFER | P55789 | 1/20 | 0.63 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.60 |
| ▸ | LMNA | P02545 | 3/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.54 |
| ▸ | MEN1 | O00255 | 4/20 | 0.54 |
| ▸ | USP2 | O75604 | 2/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | TSHR | P16473 | 2/20 | 0.52 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 2/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12274 | 0.93 | POLB (0.62) | POLBGFERPABPC1LMNATDP1 | |
| SCHEMBL11513 | 0.91 | POLB (0.60) | POLBGFERPABPC1LMNATDP1 | |
| SCHEMBL15363357 | 0.91 | POLB (0.60) | POLBGFERPABPC1LMNATDP1 | |
| SCHEMBL12011 | 0.91 | LMNA (0.68) | POLBGFERPABPC1LMNATDP1 | |
| SCHEMBL14681948 | 0.89 | POLB (0.62) | POLBGFERPABPC1KMT2AMEN1 | |
| SCHEMBL1979259 | 0.88 | PABPC1 (0.62) | POLBGFERPABPC1LMNATDP1 | |
| SCHEMBL14809 | 0.85 | ALDH1A1 (0.67) | POLBGFERPABPC1KMT2AMEN1 | |
| SCHEMBL12027 | 0.81 | LMNA (0.80) | POLBGFERLMNATDP1KMT2A | |
| SCHEMBL12112 | 0.79 | PKM (0.76) | POLBGFERPABPC1LMNAKMT2A | |
| SCHEMBL12597569 | 0.79 | PABPC1 (0.56) | POLBGFERPABPC1LMNATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140187435-A1 | METHODS AND COMPOSITIONS FOR CELL-PROLIFERATION-RELATED DISORDERS | AGIOS PHARMACEUTICALS, INC (US) | 2014-07-03 | — | — | US | disclosed |