Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | RAPGEF4 | Q8WZA2 | 2/20 | 0.41 |
| ▸ | AKT1 | P31749 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26575330 | 0.88 | ALDH1A1 (0.55) | HTTALDH1A1LMNARAPGEF4L3MBTL1 | |
| SCHEMBL23885529 | 0.80 | HTT (0.47) | HTTALDH1A1LMNASMN1; SMN2RAPGEF4 | |
| SCHEMBL30254442 | 0.80 | HTT (0.47) | HTTALDH1A1LMNASMN1; SMN2RAPGEF4 | |
| SCHEMBL2404797 | 0.79 | METAP2 (0.49) | HTTALDH1A1LMNAL3MBTL1KDM4E | |
| SCHEMBL11050934 | 0.76 | LMNA (0.38) | HTTALDH1A1LMNASMN1; SMN2RAPGEF4 | |
| SCHEMBL21104699 | 0.74 | ALDH1A1 (0.43) | HTTALDH1A1LMNASMN1; SMN2L3MBTL1 | |
| SCHEMBL26109917 | 0.74 | L3MBTL1 (0.41) | HTTALDH1A1LMNASMN1; SMN2L3MBTL1 | |
| SCHEMBL14910293 | 0.74 | ALDH1A1 (0.54) | HTTALDH1A1LMNASMN1; SMN2L3MBTL1 | |
| SCHEMBL2331083 | 0.74 | ALDH1A1 (0.47) | HTTALDH1A1SMN1; SMN2L3MBTL1 | |
| SCHEMBL2406142 | 0.73 | HTT (0.44) | HTTALDH1A1LMNAL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8772305-B2 | Substituted pyridinyl-pyrimidines and their use as medicaments | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2014-07-08 | — | — | US | disclosed |