SCHEMBL1587083

SCHEMBL1587083

CC(NC1(CN)CCNCC1)c1ccccc1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 4/20 0.39
USP2 O75604 3/20 0.39
CYP1A2 P05177 3/20 0.39
CYP2D6 P10635 3/20 0.39
CYP2C9 P11712 2/20 0.39
TAAR1 Q96RJ0 3/20 0.39
CYP2C19 P33261 2/20 0.38
OPRM1 P35372 2/20 0.36
CHRM2 P08172 1/20 0.36
HTR1A P08908 1/20 0.36
ADRA2A P08913 1/20 0.36
ADORA3 P0DMS8 1/20 0.36
CHRM1 P11229 1/20 0.36
SMPD1 P17405 1/20 0.36
DRD1 P21728 1/20 0.36
TBXA2R P21731 1/20 0.36
SLC6A2 P23975 1/20 0.36
SLC6A4 P31645 1/20 0.36
ADRA1A P35348 1/20 0.36
DRD3 P35462 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9180894 0.75 TAAR1 (0.34) CYP3A4CYP1A2CYP2D6TAAR1CYP2C19
SCHEMBL8558815 0.75 TAAR1 (0.34) CYP3A4CYP1A2CYP2D6TAAR1CYP2C19
SCHEMBL31066736 0.73 MTOR (0.43) CYP3A4TAAR1ALOX15HRH1
SCHEMBL1586715 0.70 TACR1 (0.42) CYP3A4CYP2D6CYP2C9TAAR1CYP2C19
SCHEMBL4746204 0.69 USP2 (0.44) CYP3A4USP2CYP1A2CYP2D6CYP2C9
SCHEMBL20669337 0.69 CYP1A2 (0.42) CYP3A4USP2CYP1A2CYP2D6CYP2C9
SCHEMBL20669103 0.69 CYP1A2 (0.42) CYP3A4USP2CYP1A2CYP2D6CYP2C9
SCHEMBL1586598 0.68 ALDH1A1 (0.42) CYP3A4CYP1A2CYP2D6CYP2C9TAAR1
SCHEMBL21981366 0.66 OPRM1 (0.41) CYP3A4USP2CYP1A2CYP2D6CYP2C9
SCHEMBL20669107 0.66 OPRM1 (0.41) CYP3A4USP2CYP1A2CYP2D6CYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2490687-A1 COMPOSITIONS FOR TREATMENT OF CYSTIC FIBROSIS AND OTHER CHRONIC DISEASES Vertex Pharmaceuticals Incorporated (US) 2012-08-29 EP disclosed
WO-2011050325-A1 COMPOSITIONS FOR TREATMENT OF CYSTIC FIBROSIS AND OTHER CHRONIC DISEASES VERTEX PHARMACEUTICALS INCORPORATED (US) 2011-04-28 WO disclosed