Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 4/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | TAAR1 | Q96RJ0 | 4/20 | 0.38 |
| ▸ | HTR2A | P28223 | 2/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7363061 | 0.75 | USP2 (0.50) | USP2CYP2C9CYP2D6CYP1A2CYP3A4 | |
| SCHEMBL4749593 | 0.72 | USP2 (0.47) | USP2CYP2C9CYP2D6CYP1A2CYP3A4 | |
| SCHEMBL1587083 | 0.69 | CYP3A4 (0.39) | USP2CYP2C9CYP2D6CYP1A2CYP3A4 | |
| SCHEMBL7249863 | 0.69 | POLB (0.46) | CYP1A2MEN1KMT2AALDH1A1 | |
| SCHEMBL7249473 | 0.68 | ANPEP (0.45) | CYP2C9CYP2C19MEN1KMT2ATSHR | |
| SCHEMBL3421920 | 0.68 | MAOA (0.73) | OPRM1TAAR1HTR2AMAOAMAOB | |
| SCHEMBL4749321 | 0.68 | USP2 (0.44) | USP2CYP2C9CYP2D6CYP1A2CYP3A4 | |
| SCHEMBL10639868 | 0.67 | HRH1 (0.43) | USP2CYP2C9CYP2D6CYP1A2CYP3A4 | |
| SCHEMBL3236880 | 0.67 | DPP4 (0.46) | TAAR1HTR2AMAOAMAOBSLC6A2 | |
| SCHEMBL8718738 | 0.67 | NPSR1 (0.40) | CYP1A2MEN1KMT2ATAAR1HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008124582-A1 | RENIN INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-10-16 | — | — | WO | disclosed |