Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 5/20 | 0.36 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.35 |
| ▸ | CLK1 | P49759 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23089698 | 0.89 | RAB9A (0.41) | MEN1KMT2ATDP1NPC1LMNA | |
| SCHEMBL15886759 | 0.85 | NPC1 (0.42) | NPC1LMNARAB9ASMN1; SMN2KDM4E | |
| SCHEMBL30172985 | 0.84 | ADORA2B (0.46) | MEN1KMT2ANPC1LMNARAB9A | |
| SCHEMBL24992537 | 0.84 | ADORA2B (0.46) | MEN1KMT2ANPC1LMNARAB9A | |
| SCHEMBL29736883 | 0.83 | METAP1 (0.38) | MEN1KMT2ATDP1NPC1LMNA | |
| SCHEMBL15927726 | 0.78 | MEN1 (0.38) | MEN1KMT2ATDP1RAB9AKDM4E | |
| SCHEMBL29424937 | 0.77 | LMNA (0.51) | KMT2ANPC1LMNARAB9ASMN1; SMN2 | |
| SCHEMBL1268686 | 0.77 | LMNA (0.51) | KMT2ANPC1LMNARAB9ASMN1; SMN2 | |
| SCHEMBL9280675 | 0.77 | KMT2A (0.43) | MEN1KMT2ATDP1RAB9AKDM4E | |
| SCHEMBL1269422 | 0.73 | TSHR (0.49) | MEN1KMT2ANPC1LMNARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2943481-B1 | (HETERO)ARYLACETAMIDE DERIVATIVES AS ANTIRETROVIRAL AGENTS | GILEAD SCIENCES INC (US) | 2018-05-02 | — | — | EP | disclosed |
| EP-2943481-A1 | (HETERO) ARYLACETAMIDE DERIVATIVES AS ANTIRETROVIRAL AGENTS | Gilead Sciences, Inc. (US) | 2015-11-18 | — | — | EP | disclosed |
| US-9050344-B2 | Therapeutic compounds | GILEAD SCIENCES, INC. (US) | 2015-06-09 | — | — | US | disclosed |
| US-9050344-B2 | Therapeutic compounds | GILEAD SCIENCES, INC. (US) | 2015-06-09 | — | — | US | disclosed |
| US-20140221346-A1 | THERAPEUTIC COMPOUNDS | GILEAD SCIENCES, INC. (US) | 2014-08-07 | — | — | US | disclosed |
| US-20140221346-A1 | THERAPEUTIC COMPOUNDS | GILEAD SCIENCES, INC. (US) | 2014-08-07 | — | — | US | disclosed |
| US-20140221347-A1 | THERAPEUTIC COMPOUNDS | GILEAD SCIENCES, INC. (US) | 2014-08-07 | — | — | US | disclosed |
| WO-2014110297-A1 | (HETERO) ARYLACETAMIDE DERIVATIVES AS ANTIRETROVIRAL AGENTS | GILEAD SCIENCES, INC. (US) | 2014-07-17 | — | — | WO | disclosed |
| US-7648572-B2 | Non-aqueous pigment dispersions using dispersion synergists | AGFA GRAPHICS NV (BE) | 2010-01-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140221347-A1 | THERAPEUTIC COMPOUNDS | HAVCR2, SARS1, FURIN | MEN1 2383/4885KMT2A 4773/4885TDP1 1898/4885 |
| US-20140221346-A1 | THERAPEUTIC COMPOUNDS | HAVCR2, SARS1, G6PD | MEN1 2641/4885KMT2A 4702/4885TDP1 1782/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.